ENSDARG00000057096


Danio rerio

Features
Gene ID: ENSDARG00000057096
  
Biological name :ndr1
  
Synonyms : ndr1 / nodal-related 1
  
Possible biological names infered from orthology : NODAL / nodal growth differentiation factor / P43021 / Q96S42
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 21010786
Gene end: 21013085
  
Corresponding Affymetrix probe sets: Dr.20960.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074144
Ensembl peptide - ENSDARP00000149018
NCBI entrez gene - 799352     See in Manteia.
RefSeq - NM_130966
RefSeq Peptide - NP_571041
swissprot - F1QDT8
ZFIN ID - ZDB-GENE-990415-256
Ensembl - ENSDARG00000057096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003209Gallus gallus
 NODALENSG00000156574Homo sapiens
 NodalENSMUSG00000037171Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430945
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127931
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799519
tgfb3 / transforming growth factor, beta 3 / P10600*ENSDARG0000001936718
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077718
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000007389118
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537818
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267118
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052618
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098617
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475917
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187916
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150216
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489516
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389215
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708715
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*ENSDARG0000006913315
bmp15 / bone morphogenetic protein 15ENSDARG0000003749115
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492414
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0008595 anterior/posterior axis specification, embryo IMP
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0048263 determination of dorsal identity IDA
 biological_processGO:0048382 mesendoderm development IMP
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060061 Spemann organizer formation IMP
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm endodermal cell decreased amount , abnormal
endoderm endodermal cell increased amount , abnormal
endoderm aplastic , abnormal
endoderm absent , abnormal
Show

 ZFA:0000019 epiphysis epiphysis split bilaterally , abnormal
epiphysis morphology , abnormal
epiphysis split , abnormal
epiphysis oblong , abnormal
Show

 ZFA:0000022 floor plate floor plate malformed , abnormal
floor plate decreased amount , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group increased amount , abnormal
Show

 ZFA:0000031 hypochord hypochord decreased amount , abnormal
Show

 ZFA:0000041 mesoderm mesoderm absent , abnormal
Show

 ZFA:0000058 polster polster aplastic , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate quality , abnormal
prechordal plate decreased size , abnormal
Show

 ZFA:0000071 shield shield morphology , abnormal
shield aplastic , abnormal
shield decreased amount , abnormal
Show

 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm disorganized , abnormal
Show

 ZFA:0000092 axis axis malformed , abnormal
axis physical object quality , abnormal
axis decreased length , abnormal
Show

 ZFA:0000101 diencephalon diencephalon ventral region decreased size , abnormal
Show

 ZFA:0000106 extension extension aplastic , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye fused with eye , abnormal
eye decreased distance eye , abnormal
eye malformed , abnormal
eye mislocalised , abnormal
eye decreased amount , abnormal
eye aplastic , abnormal
Show

 ZFA:0000109 forebrain forebrain aplastic , abnormal
Show

 ZFA:0000112 gut gut duplicated , abnormal
Show

 ZFA:0000135 notochord notochord malformed , abnormal
notochord decreased amount , abnormal
notochord aplastic/hypoplastic , abnormal
notochord decreased thickness , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite U-shaped , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000329 chorion chorion present , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000445 optic tectum optic tectum morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved ventral , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001114 head head decreased width , abnormal
head morphology , abnormal
head hypoplastic , abnormal
head sharpness , abnormal
head paraxial mesoderm decreased amount , abnormal
head paraxial mesoderm aplastic/hypoplastic , abnormal
head mesoderm aplastic , abnormal
Show

 ZFA:0001115 trunk trunk duplicated , abnormal
trunk anterior-posterior axis bifurcated , abnormal
trunk spinal cord neural tube duplicated , abnormal
trunk mesoderm aplastic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region malformed , abnormal
post-vent region undulate , abnormal
Show

 ZFA:0001120 neuroectoderm neuroectoderm anterior region truncated , abnormal
neuroectoderm anterior region absent , abnormal
Show

 ZFA:0001135 neural tube neural tube open , abnormal
Show

 ZFA:0001340 nucleus of the tract of the postoptic commissure nucleus of the tract of the postoptic commissure absent , abnormal
Show

 ZFA:0001359 pineal complex pineal complex elongated , abnormal
pineal complex split , abnormal
Show

 ZFA:0009151 hatching gland cell hatching gland cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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