ENSDARG00000019367


Danio rerio

Features
Gene ID: ENSDARG00000019367
  
Biological name :tgfb3
  
Synonyms : tgfb3 / transforming growth factor, beta 3
  
Possible biological names infered from orthology : P10600
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 52059020
Gene end: 52091999
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000025519
NCBI entrez gene - 369195     See in Manteia.
swissprot - Q66I23
ZFIN ID - ZDB-GENE-030723-4
Ensembl - ENSDARG00000019367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TGFB3ENSGALG00000010346Gallus gallus
 TGFB3ENSG00000119699Homo sapiens
 Tgfb3ENSMUSG00000021253Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*ENSDARG0000002708756
tgfb2l / transforming growth factor, beta 2, likeENSDARG0000007187949
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*ENSDARG0000003489539
tgfb1a / transforming growth factor, beta 1a / TGFB1* / P01137* / transforming growth factor beta 1*ENSDARG0000004150238
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*ENSDARG0000006913324
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*ENSDARG0000004294722
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*ENSDARG0000004492422
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000002475921
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*ENSDARG0000001267120
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*ENSDARG0000010098620
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSDARG0000004077719
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...ENSDARG0000003799519
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*ENSDARG0000005709617
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*ENSDARG0000010127916
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSDARG0000001430915
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*ENSDARG0000009537815
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *ENSDARG0000006052614
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*ENSDARG0000010389214
bmp15 / bone morphogenetic protein 15ENSDARG0000003749113
gdf9 / growth differentiation factor 9 / O60383* / Q07105*ENSDARG0000000322913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015618  Transforming growth factor beta-3
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060218 hematopoietic stem cell differentiation IGI
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061035 regulation of cartilage development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium increased size , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton hypoplastic , abnormal
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 ZFA:0000114 heart heart decreased size , abnormal
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 ZFA:0000184 cleithrum cleithrum ossified , abnormal
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 ZFA:0000250 opercle opercle osteoblast poorly differentiated , abnormal
opercle ossified , abnormal
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 ZFA:0000270 maxilla maxilla ossified , abnormal
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 ZFA:0000476 branchiostegal ray branchiostegal ray osteoblast poorly differentiated , abnormal
branchiostegal ray ossified , abnormal
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 ZFA:0000547 mouth mouth ventrally rotated head , abnormal
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 ZFA:0000561 parasphenoid parasphenoid ossified , abnormal
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 ZFA:0000578 ceratohyal bone ceratohyal bone ossified , abnormal
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 ZFA:0000621 quadrate quadrate ossified , abnormal
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 ZFA:0000657 entopterygoid entopterygoid ossified , abnormal
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 ZFA:0000672 hyomandibula hyomandibula ossified , abnormal
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 ZFA:0001078 thymus thymus T cell absent , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001189 vertebra vertebra ossified , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
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 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone ossified , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch malformed , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch apoptotic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage hypoplastic , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage hypoplastic , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage hypoplastic , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage aplastic , abnormal
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 ZFA:0001580 neurocranium neurocranium decreased size , abnormal
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 ZFA:0001631 notochordal ossification notochordal ossification ossified , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019367 tgfb3 / transforming growth factor, beta 3 / P10600*  / complex
 ENSDARG00000035682 FP102018.1 / Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA. / LTBP3* / Q9NS15* / latent transforming growth factor beta binding protein 3*  / reaction / complex
 ENSDARG00000056922 ltbp1 / latent transforming growth factor beta binding protein 1 / Q14766* / Q8CG19*  / reaction / complex






 

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