Manteia

ENSDARG00000041502

Danio rerio

Features

Gene ID:	ENSDARG00000041502

Biological name :	tgfb1a

Synonyms :	tgfb1a / transforming growth factor, beta 1a

Possible biological names infered from orthology :	P01137 / P04202 / TGFB1 / transforming growth factor beta 1

Species:	Danio rerio

Chr. number:	15
Strand:	-1
Band:
Gene start:	2776506
Gene end:	2803313

Corresponding Affymetrix probe sets:	Dr.20238.1.A1_at (Zebrafish Array) DrAffx.1.32.S1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000060838 swissprot - F1R741 ZFIN ID - ZDB-GENE-030618-1 Ensembl - ENSDARG00000041502

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
TGFB1	ENSG00000105329	Homo sapiens
Tgfb1	ENSMUSG00000002603	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
tgfb1b / transforming growth factor, beta 1b / TGFB1* / P04202* / P01137* / transforming growth factor beta 1*	ENSDARG00000034895	54
tgfb3 / transforming growth factor, beta 3 / P10600*	ENSDARG00000019367	41
tgfb2 / transforming growth factor, beta 2 / P27090* / P61812* / Transforming growth factor beta-2 Latency-associated peptide*	ENSDARG00000027087	40
tgfb2l / transforming growth factor, beta 2, like	ENSDARG00000071879	39
mstnb / O42222 / myostatin b / MSTN* / O08689* / O14793* / myostatin*	ENSDARG00000069133	24
gdf11 / growth differentiation factor 11 / O95390* / Q9Z1W4*	ENSDARG00000044924	22
inhbaa / inhibin, beta Aa / INHBA* / P08476* / inhibin beta A subunit*	ENSDARG00000012671	21
mstna / myostatin a / MSTN* / O14793* / O08689* / myostatin*	ENSDARG00000042947	21
inhbab / inhibin, beta Ab / INHBA* / P08476* / inhibin beta A subunit*	ENSDARG00000024759	20
INHBE / inhibin beta E subunit / INHBC* / P58166* / P55103* / inhibin beta C subunit*	ENSDARG00000100986	19
inhbb / inhibin, beta B / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*	ENSDARG00000040777	18
gdf3 / P35621 / growth differentiation factor 3 / GDF1* / CERS1* / Q9NR23* / P27544* / P27545* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 1* / Embr...	ENSDARG00000037995	18
ndr2 / nodal-related 2 / NODAL* / Q96S42* / nodal growth differentiation factor*	ENSDARG00000101279	16
gdf10a / growth differentiation factor 10a / GDF10* / P97737* / P55107* / growth differentiation factor 10*	ENSDARG00000095378	16
ndr1 / nodal-related 1 / NODAL* / Q96S42* / P43021* / nodal growth differentiation factor*	ENSDARG00000057096	16
bmp3 / bone morphogenetic protein 3 / P12645* / Q8BHE5* / Bone morphotic protein 3 *	ENSDARG00000060526	15
gdf10b / growth differentiation factor 10b / GDF10* / P97737* / P55107* / growth differentiation factor 10*	ENSDARG00000073891	15
spaw / southpaw / NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*	ENSDARG00000014309	15
CABZ01074203.1 / INHBB* / P09529* / inhibin beta B subunit*	ENSDARG00000103892	14
bmp15 / bone morphogenetic protein 15	ENSDARG00000037491	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR001111	TGF-beta, propeptide
IPR001839	Transforming growth factor-beta, C-terminal
IPR003939	Transforming growth factor, beta 1
IPR015615	Transforming growth factor-beta-related
IPR016319	Transforming growth factor-beta
IPR017948	Transforming growth factor beta, conserved site
IPR029034	Cystine-knot cytokine

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
biological_process	GO:0030509	BMP signaling pathway	IBA
biological_process	GO:0035677	posterior lateral line neuromast hair cell development	IMP
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043408	regulation of MAPK cascade	IBA
biological_process	GO:0048840	otolith development	IMP
biological_process	GO:0048919	posterior lateral line neuromast development	IMP
biological_process	GO:0048920	posterior lateral line neuromast primordium migration	IMP
biological_process	GO:0048922	posterior lateral line neuromast deposition	IMP
biological_process	GO:0060218	hematopoietic stem cell differentiation	IGI
biological_process	GO:0060395	SMAD protein signal transduction	IBA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
molecular_function	GO:0005114	type II transforming growth factor beta receptor binding	IBA
molecular_function	GO:0005125	cytokine activity	IBA
molecular_function	GO:0005160	transforming growth factor beta receptor binding	IEA
molecular_function	GO:0008083	growth factor activity	IEA

Pathways (from Reactome)

Pathway description

Platelet degranulation

Cell surface interactions at the vascular wall

Molecules associated with elastic fibres

Downregulation of TGF-beta receptor signaling

TGF-beta receptor signaling activates SMADs

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Syndecan interactions

RUNX3 regulates CDKN1A transcription

Regulation of RUNX3 expression and activity

RUNX3 regulates p14-ARF

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000940	posterior lateral line neuromast	posterior lateral line neuromast irregular spatial pattern , abnormal posterior lateral line neuromast decreased amount , abnormal posterior lateral line neuromast far from posterior lateral line neuromast , abnormal posterior lateral line neuromast neuromast hair cell decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr