ENSMUSG00000002603


Mus musculus

Features
Gene ID: ENSMUSG00000002603
  
Biological name :Tgfb1
  
Synonyms : P04202 / Tgfb1 / transforming growth factor, beta 1
  
Possible biological names infered from orthology : P01137
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 25687002
Gene end: 25705077
  
Corresponding Affymetrix probe sets: 10551185 (MoGene1.0st)   1420653_at (Mouse Genome 430 2.0 Array)   1445360_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130413
Ensembl peptide - ENSMUSP00000002678
NCBI entrez gene - 21803     See in Manteia.
MGI - MGI:98725
RefSeq - NM_011577
RefSeq Peptide - NP_035707
swissprot - E9Q6I6
swissprot - P04202
swissprot - Q3UNK5
Ensembl - ENSMUSG00000002603
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfb1aENSDARG00000041502Danio rerio
 tgfb1bENSDARG00000034895Danio rerio
 TGFB1ENSG00000105329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgfb3 / transforming growth factor, beta 3 / P10600*ENSMUSG0000002125348
Tgfb2 / P27090 / Transforming growth factor beta-2 Latency-associated peptide / P61812* / transforming growth factor beta 2*ENSMUSG0000003923947
Mstn / O08689 / myostatin / O14793*ENSMUSG0000002610025
Gdf11 / Q9Z1W4 / Growth/differentiation factor 11 / O95390*ENSMUSG0000002535224
Inhba / Q04998 / Inhibin beta A chain / P08476* / inhibin beta A subunit*ENSMUSG0000004132422
Inhbe / O08717 / Inhibin beta E chain / P58166* / inhibin beta E subunit*ENSMUSG0000004749221
Inhbb / Q04999 / Inhibin beta B chain / P09529* / inhibin beta B subunit*ENSMUSG0000003703519
Gdf1 / P20863 / Embryonic growth/differentiation factor 1 / CERS1* / P27544* / P27539* / ceramide synthase 1* / growth differentiation factor 1*ENSMUSG0000010952317
Cers1 / P20863 / P27545 / Ceramide synthase 1 / GDF1* / P27539* / P27544* / growth differentiation factor 1*ENSMUSG0000008740817
Gdf3 / Q07104 / Growth/differentiation factor 3 / Q9NR23*ENSMUSG0000003011717
Nodal / P43021 / Q96S42* / nodal growth differentiation factor*ENSMUSG0000003717117
Inhbc / P55104 / Inhibin beta C chain / P55103* / inhibin beta C subunit*ENSMUSG0000002540516
Gdf10 / P97737 / Growth/differentiation factor 10 / P55107*ENSMUSG0000002194315
Bmp15 / Q9Z0L4 / Bone morphotic protein 15 / O95972* / bone morphogenetic protein 15*ENSMUSG0000002327915
Gdf9 / Q07105 / Growth/differentiation factor 9 / O60383*ENSMUSG0000001823814
Bmp3 / Q8BHE5 / Bone morphotic protein 3 / P12645* / bone morphogenetic protein 3*ENSMUSG0000002933513
Gdf15 / Q9Z0J7 / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA. / Q99988* / growth differentiation factor 15*ENSMUSG0000003850812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003939  Transforming growth factor, beta 1
 IPR015615  Transforming growth factor-beta-related
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001763 morphogenesis of a branching structure IEA
 biological_processGO:0001775 cell activation IDA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002028 regulation of sodium ion transport IDA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment TAS
 biological_processGO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDA
 biological_processGO:0002513 tolerance induction to self antigen IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0006796 phosphate-containing compound metabolic process IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IEA
 biological_processGO:0007183 SMAD protein complex assembly IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007406 negative regulation of neuroblast proliferation IEA
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0007492 endoderm development IDA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007519 skeletal muscle tissue development TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008354 germ cell migration IDA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009817 defense response to fungus, incompatible interaction IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0010936 negative regulation of macrophage cytokine production IEA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016049 cell growth IEA
 biological_processGO:0016202 regulation of striated muscle tissue development IDA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0019049 evasion or tolerance of host defenses by virus IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030214 hyaluronan catabolic process IEA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030279 negative regulation of ossification IDA
 biological_processGO:0030308 negative regulation of cell growth ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0030879 mammary gland development IDA
 biological_processGO:0031065 positive regulation of histone deacetylation IDA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031536 positive regulation of exit from mitosis IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032667 regulation of interleukin-23 production IDA
 biological_processGO:0032700 negative regulation of interleukin-17 production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production ISS
 biological_processGO:0032801 receptor catabolic process IEA
 biological_processGO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation TAS
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0032943 mononuclear cell proliferation IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0035066 positive regulation of histone acetylation IDA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042306 regulation of protein import into nucleus IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042482 positive regulation of odontogenesis IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042552 myelination IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0043932 ossification involved in bone remodeling IEA
 biological_processGO:0045066 regulatory T cell differentiation IMP
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IGI
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes ISO
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051098 regulation of binding IDA
 biological_processGO:0051101 regulation of DNA binding IDA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation ISO
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060325 face morphogenesis IEP
 biological_processGO:0060364 frontal suture morphogenesis IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISS
 biological_processGO:0060390 regulation of SMAD protein signal transduction IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060744 mammary gland branching involved in thelarche IMP
 biological_processGO:0060751 branch elongation involved in mammary gland duct branching IMP
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IGI
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IEA
 biological_processGO:0061035 regulation of cartilage development IDA
 biological_processGO:0070306 lens fiber cell differentiation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070723 response to cholesterol IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071677 positive regulation of mononuclear cell migration IEA
 biological_processGO:0072540 T-helper 17 cell lineage commitment TAS
 biological_processGO:0085029 extracellular matrix assembly ISS
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1900126 negative regulation of hyaluronan biosynthetic process IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IGI
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity IEA
 biological_processGO:1902074 response to salt IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1903911 positive regulation of receptor clustering IDA
 biological_processGO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development IMP
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:1990402 embryonic liver development IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IGI
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0072562 blood microparticle ISS
 molecular_functionGO:0003823 antigen binding IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding TAS
 molecular_functionGO:0005515 protein binding ISS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000129 ameloblast degeneration "a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Fbn1Tsk/Fbn1+,Il4ratm1Sz/Il4ra+
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Oca2p-116G/Oca2p-116G
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001652 colonic necrosis "pathologic death of cells within, or a portion of, the colon" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001653 gastric necrosis "pathologic death of cells within, or a portion of, the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Shr/Cd28tm1Shr
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Ighmtm1Cgn/Ighm+,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0001854 atrial endocarditis "inflammation affecting the atrial chambers of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001857 pericarditis "inflammation of the pericaridum, the fibroserous sac surrounding the heart and the roots of the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm2.1Doe,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * BALB/c * C57BL/6 * CBA

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu/Foxn1nu,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1Ywc/Tnfsf11+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Foxn1nu/Foxn1nu,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Cd8atm1Mak/Cd8atm1Mak,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: Cd4tm1Knw/Cd4tm1Knw,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu/Foxn1nu,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002817 abnormal tooth mineralization "abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0003282 gastric ulcer "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0003305 proctitis "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0003543 abnormal vascular endothelial cell differentiation "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0003865 lymph node inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004820 abnormal urine potassium level "anomaly in the normal amount of this alkaline metallic element, the most abundant intracellular ion, found in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Tgfb1tm3.1Flv/Tgfb1tm3.1Flv,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

Allelic Composition: Tgfb1tm3.1Flv/Tgfb1tm3.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CF-1

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0006375 increased circulating angiotensinogen level "greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0006376 decreased circulating angiotensinogen level "less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0008010 gastric adenocarcinoma "malignant neoplasm of epithelial cells in the stomach" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Tgfb1tm3.1Flv/Tgfb1tm3.1Flv,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

Allelic Composition: Tgfb1tm3.1Flv/Tgfb1tm3.1Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Endogtm1Vdaw/Endogtm1Vdaw
Genetic Background: involves: 129S6/SvEvTac * ICR

Allelic Composition: Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv,Tg(CD207-cre)1Dhka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tgfb1tm1N/Tgfb1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Tg(Lck-cre)548Jxm/?,Tgfb1tm2.1Doe/Tgfb1tm2.1Doe
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0009310 large intestine adenocarcinoma "malignant neoplasm of epithelial cells in the large intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0009315 rectum adenocarcinoma "malignant neoplasm of epithelial cells in the rectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0009316 anal adenocarcinoma "malignant neoplasm of epithelial cells in the anal canal" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0009697 abnormal copulation "an anomaly in sexual union that normally enables the transfer of ejaculate (sperm) from male to female, sometimes resulting in the fertilization of an egg" [GO:0007620, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0009856 failure of ejaculation "inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkdcscid/Prkdcscid,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129 * C3H * CF-1

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010096 abnormal incisor color "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010127 hypervolemia "an abnormally increased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0010128 hypovolemia "an abnormally decreased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0010140 phlebitis "inflammation of a vein" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfb1tm1Rif/Tgfb1tm1Rif
Genetic Background: either: (involves: 129) or (involves: 129S/SvEv * C57BL/6)

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Jmu/Tgfb1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129S2-Tgfb1tm1Doe

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * BALB/c * C57BL/6J * Swiss Webster

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Tgfb1tm1N/Tgfb1+
Genetic Background: involves: 129S/SvEv * C57BL/6J * NIH/Ola

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * Swiss Webster

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Tgfb1tm1Jmu/Tgfb1tm1Jmu,Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic Background: involves: 129 * C57BL/6J * ICR * Swiss Webster

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gja8R205G/Gja8R205G
Genetic Background: CWXS/Agl-Gja8R205G

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Stat5btm1Hwd/Stat5btm1Hwd
Genetic Background: involves: 129 * BALB/c

 MP:0013467 diaphragmitis "inflammation of the diaphragm" [MGI:Anna]
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Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0030459 abnormal tooth attrition "change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030541 misaligned incisors "abnormal alignment of the upper and lower incisor teeth, usually resulting in malocclusion; in gnawing rodents, where incisors are rootless and grow continually, signs of incisor malocclusion include uneven wear patterns, sloping of the cutting edges, fractured teeth, altered pigmentation, and obvious pathological overgrowth of the incisors" [HP:0011062, https://books.google.com/books?isbn=0323394302, PMID:19622764]
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Allelic Composition: Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001870 Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*  / complex / reaction
 ENSMUSG00000032966 Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*  / reaction
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / complex / reaction
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / complex
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction / complex
 ENSMUSG00000040488 Ltbp4 / Q8K4G1 / Latent-transforming growth factor beta-binding protein 4 / Q8N2S1*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000024232 Bambi / Q9D0L6 / BMP and activin membrane-bound inhibitor homolog / Q13145* / BMP and activin membrane bound inhibitor*  / reaction / complex
 ENSMUSG00000034557 Zfyve9 / zinc finger, FYVE domain containing 9 / O95405* / zinc finger FYVE-type containing 9*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction
 ENSMUSG00000030224 Strap / Q9Z1Z2 / serine/threonine kinase receptor associated protein / Q9Y3F4*  / complex
 ENSMUSG00000024940 Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*  / complex / reaction
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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