ENSMUSG00000040488


Mus musculus

Features
Gene ID: ENSMUSG00000040488
  
Biological name :Ltbp4
  
Synonyms : Latent-transforming growth factor beta-binding protein 4 / Ltbp4 / Q8K4G1
  
Possible biological names infered from orthology : Q8N2S1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 27305136
Gene end: 27337692
  
Corresponding Affymetrix probe sets: 10561212 (MoGene1.0st)   1436665_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113674
Ensembl peptide - ENSMUSP00000113523
Ensembl peptide - ENSMUSP00000113746
Ensembl peptide - ENSMUSP00000120326
Ensembl peptide - ENSMUSP00000037536
Ensembl peptide - ENSMUSP00000104006
NCBI entrez gene - 108075     See in Manteia.
MGI - MGI:1321395
RefSeq - XM_006539458
RefSeq - NM_001113549
RefSeq - NM_001310678
RefSeq - NM_175641
RefSeq - XM_006539457
RefSeq Peptide - NP_001297607
RefSeq Peptide - NP_001107021
RefSeq Peptide - NP_783572
swissprot - F6W6Z0
swissprot - E9Q6B8
swissprot - E9QPS5
swissprot - D3Z598
swissprot - Q8K4G1
Ensembl - ENSMUSG00000040488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX663503.3ENSDARG00000099137Danio rerio
 LTBP4ENSG00000090006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ltbp2 / latent transforming growth factor beta binding protein 2 / Q14767*ENSMUSG0000000202036
Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*ENSMUSG0000000187035
Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*ENSMUSG0000002459828
Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*ENSMUSG0000002720427
Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*ENSMUSG0000002494026
Fbln2 / P37889 / Fibulin-2 / P98095*ENSMUSG0000006408015
Fbln1 / Q08879 / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA. / P23142* / fibulin 1*ENSMUSG0000000636911
Efemp1 / Q8BPB5 / EGF-containing fibulin-like extracellular matrix protein 1 / Q12805* / EGF containing fibulin extracellular matrix protein 1*ENSMUSG000000204677
Fbln5 / Q9WVH9 / Fibulin-5 / Q9UBX5*ENSMUSG000000211867
Efemp2 / Q9WVJ9 / EGF-containing fibulin-like extracellular matrix protein 2 / O95967* / EGF containing fibulin extracellular matrix protein 2*ENSMUSG000000249097


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017878  TB domain
 IPR018097  EGF-like calcium-binding, conserved site
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030162 regulation of proteolysis ISO
 biological_processGO:0046879 hormone secretion IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding ISO


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Tyrc-Bc3/Tyrc-Bc3
Genetic Background: SELH/Bc

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tsc2tm1.1Mjg/Tsc2tm1.1Mjg,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Tyrc-Bc3/Tyrc-Bc3
Genetic Background: SELH/Bc

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0002952 ventricular cardiomyopathy "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0003305 proctitis "local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0009310 large intestine adenocarcinoma "malignant neoplasm of epithelial cells in the large intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Paqr3tm1Ychn/Paqr3+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ltbp4dmod1-DBA/2J/Ltbp4dmod1-DBA/2J,Sgcgtm1Mcn/Sgcgtm1Mcn
Genetic Background: D2.Cg-Ltbp4dmod1-DBA/2J Sgcgtm1Mcn

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Genetic Background: B6.129S2-Ltbp4Gt(U3Cre)1Vmel

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ltbp4Gt(E301B04)Wrst/Ltbp4Gt(E301B04)Wrst
Genetic Background: B6N.129P2-Ltbp4Gt(E301B04)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / complex / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction / complex






 

1 s.

 
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