ENSMUSG00000002020


Mus musculus

Features
Gene ID: ENSMUSG00000002020
  
Biological name :Ltbp2
  
Synonyms : latent transforming growth factor beta binding protein 2 / Ltbp2
  
Possible biological names infered from orthology : Q14767
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 84783212
Gene end: 84876532
  
Corresponding Affymetrix probe sets: 10401527 (MoGene1.0st)   1418061_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132067
Ensembl peptide - ENSMUSP00000127693
Ensembl peptide - ENSMUSP00000132690
Ensembl peptide - ENSMUSP00000002073
Ensembl peptide - ENSMUSP00000105883
Ensembl peptide - ENSMUSP00000127255
NCBI entrez gene - 16997     See in Manteia.
MGI - MGI:99502
RefSeq - XM_017314966
RefSeq - NM_013589
RefSeq - XM_006515501
RefSeq - XM_006515502
RefSeq Peptide - NP_038617
swissprot - E9Q1D6
swissprot - E9QNQ3
swissprot - F6UFW9
swissprot - F6WSP3
swissprot - F6XGT5
swissprot - Q0VD84
Ensembl - ENSMUSG00000002020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LTBP2ENSGALG00000010258Gallus gallus
 LTBP2ENSG00000119681Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*ENSMUSG0000000187037
Ltbp4 / Q8K4G1 / Latent-transforming growth factor beta-binding protein 4 / Q8N2S1*ENSMUSG0000004048833
Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*ENSMUSG0000002459827
Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*ENSMUSG0000002720427
Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*ENSMUSG0000002494025
Fbln2 / P37889 / Fibulin-2 / P98095*ENSMUSG0000006408015
Fbln1 / Q08879 / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA. / P23142* / fibulin 1*ENSMUSG0000000636910
Efemp1 / Q8BPB5 / EGF-containing fibulin-like extracellular matrix protein 1 / Q12805* / EGF containing fibulin extracellular matrix protein 1*ENSMUSG000000204676
Fbln5 / Q9WVH9 / Fibulin-5 / Q9UBX5*ENSMUSG000000211866
Efemp2 / Q9WVJ9 / EGF-containing fibulin-like extracellular matrix protein 2 / O95967* / EGF containing fibulin extracellular matrix protein 2*ENSMUSG000000249096


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017878  TB domain
 IPR018097  EGF-like calcium-binding, conserved site
 IPR036773  TGF-beta binding (TB) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0097435 supramolecular fiber organization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0005263 ectopia lentis "congenital displacement of the lens due to defective zonule formation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0014176 abnormal cilary zonule morphology "any structural anomaly of the circumferential suspensory ligaments that anchor the lens to the ciliary process and are made of bundles of fibrillin microfibrils, an elaborate system of fibers that spans the gap between the lens and the adjacent nonpigmented ciliary epithelium; this fibrous rigging ensures lens centration; in species that accommodate, the zonule transmits the forces that flatten the lens, allowing the eye to focus on distant objects" [PMID:23493297, PMID:24908666]
Show

Allelic Composition: Bgntm1Mfy/Bgntm1Mfy
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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