ENSMUSG00000021186


Mus musculus

Features
Gene ID: ENSMUSG00000021186
  
Biological name :Fbln5
  
Synonyms : Fbln5 / Fibulin-5 / Q9WVH9
  
Possible biological names infered from orthology : Q9UBX5
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 101746565
Gene end: 101819055
  
Corresponding Affymetrix probe sets: 10402211 (MoGene1.0st)   1416164_at (Mouse Genome 430 2.0 Array)   1446377_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021603
Ensembl peptide - ENSMUSP00000152680
NCBI entrez gene - 23876     See in Manteia.
MGI - MGI:1346091
RefSeq - XM_006515866
RefSeq - NM_011812
RefSeq - XM_006515864
RefSeq - XM_006515865
RefSeq Peptide - NP_035942
swissprot - A0A1Y7VJW9
swissprot - Q9WVH9
Ensembl - ENSMUSG00000021186
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbln5ENSDARG00000039273Danio rerio
 FBLN5ENSGALG00000010747Gallus gallus
 FBLN5ENSG00000140092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efemp2 / Q9WVJ9 / EGF-containing fibulin-like extracellular matrix protein 2 / O95967* / EGF containing fibulin extracellular matrix protein 2*ENSMUSG0000002490948
Efemp1 / Q8BPB5 / EGF-containing fibulin-like extracellular matrix protein 1 / Q12805* / EGF containing fibulin extracellular matrix protein 1*ENSMUSG0000002046745
Fbln1 / Q08879 / Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA. / P23142* / fibulin 1*ENSMUSG0000000636934
Fbln2 / P37889 / Fibulin-2 / P98095*ENSMUSG0000006408034
Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*ENSMUSG0000002720428
Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*ENSMUSG0000002459827
Ltbp4 / Q8K4G1 / Latent-transforming growth factor beta-binding protein 4 / Q8N2S1*ENSMUSG0000004048826
Ltbp1 / Q8CG19 / Latent-transforming growth factor beta-binding protein 1 / Q14766*ENSMUSG0000000187025
Ltbp2 / latent transforming growth factor beta binding protein 2 / Q14767*ENSMUSG0000000202025
Ltbp3 / latent transforming growth factor beta binding protein 3 / Q9NS15*ENSMUSG0000002494019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR037287  Fibulin 3/4/5
 IPR037288  Fibulin-5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0034394 protein localization to cell surface IMP
 biological_processGO:0046903 secretion IEA
 biological_processGO:0048251 elastic fiber assembly IEA
 biological_processGO:2000121 regulation of removal of superoxide radicals IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0071953 elastic fiber IDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002268 abnormal terminal bronchiole morphology "any structural anomaly of the last conducting structure of bronchioles; after this point, the airways have alveoli in their walls " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Hiya/Fbln5tm1Hiya
Genetic Background: involves: 129S6/SvEvTac

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Krc/Fbln5tm1Krc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Fbln5tm1Hiya/Fbln5tm1Hiya
Genetic Background: involves: 129S6/SvEvTac

 MP:0006083 abnormal vascular elastic tissue "malformation in the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Lrp5tm1Jsak/Lrp5+
Genetic Background: involves: C57BL/6 * CBA

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Artm1Ska/Y,Tg(CMV-cre)1Ipc/?
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029675 Eln / P54320 / Elastin / P15502*  / complex
 ENSMUSG00000024529 Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex
 ENSMUSG00000060572 Mfap2 / microfibril associated protein 2 / P55001*  / complex
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / complex
 ENSMUSG00000030116 Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*  / complex
 ENSMUSG00000029163 Q99K41 / Emilin1 / Q9Y6C2* / elastin microfibril interfacer 1*  / reaction / complex
 ENSMUSG00000032334 Loxl1 / lysyl oxidase like 1 / Q08397*  / reaction






 

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