ENSMUSG00000032334


Mus musculus

Features
Gene ID: ENSMUSG00000032334
  
Biological name :Loxl1
  
Synonyms : Loxl1 / lysyl oxidase like 1
  
Possible biological names infered from orthology : Q08397
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 58287738
Gene end: 58313186
  
Corresponding Affymetrix probe sets: 10594066 (MoGene1.0st)   1436063_at (Mouse Genome 430 2.0 Array)   1451978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057406
NCBI entrez gene - 16949     See in Manteia.
MGI - MGI:106096
RefSeq - NM_010729
RefSeq Peptide - NP_034859
swissprot - A0A0R4J0Q4
Ensembl - ENSMUSG00000032334
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 loxl1ENSDARG00000054451Danio rerio
 LOXL1ENSG00000129038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG0000002452936
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069328
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518527
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420526
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG000000246708
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG000000263905
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG000000220325
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG000000250444


Protein motifs (from Interpro)
Interpro ID Name
 IPR001695  Lysyl oxidase
 IPR013783  Immunoglobulin-like fold
 IPR019828  Lysyl oxidase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0001136 dilated cervix "stretched or enlarged lower opening of the uterus to the vagina" [J:50844]
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Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0005577 uterine prolapse "downward movement, and possible external appearance, of the uterus through the vagina" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88284]
Show

Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0008418 abnormal cutaneous elastic fiber morphology "any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raratm2Ipc/Raratm2Ipc,Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022098 Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*  / reaction
 ENSMUSG00000053626 Tll1 / tolloid-like / O43897* / tolloid like 1*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000021186 Fbln5 / Q9WVH9 / Fibulin-5 / Q9UBX5*  / reaction
 ENSMUSG00000030116 Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*  / reaction
 ENSMUSG00000029675 Eln / P54320 / Elastin / P15502*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000060572 Mfap2 / microfibril associated protein 2 / P55001*  / reaction






 

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