ENSMUSG00000024529


Mus musculus

Features
Gene ID: ENSMUSG00000024529
  
Biological name :Lox
  
Synonyms : Lox / P28301 / Protein-lysine 6-oxidase
  
Possible biological names infered from orthology : lysyl oxidase / P28300
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: D1
Gene start: 52516069
Gene end: 52529867
  
Corresponding Affymetrix probe sets: 10458894 (MoGene1.0st)   1416121_at (Mouse Genome 430 2.0 Array)   1437903_at (Mouse Genome 430 2.0 Array)   1448228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025409
Ensembl peptide - ENSMUSP00000129247
NCBI entrez gene - 16948     See in Manteia.
MGI - MGI:96817
RefSeq - NM_010728
RefSeq - NM_001286181
RefSeq - NM_001286182
RefSeq Peptide - NP_001273110
RefSeq Peptide - NP_001273111
RefSeq Peptide - NP_034858
swissprot - P28301
swissprot - Q3TXH3
Ensembl - ENSMUSG00000024529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LOXENSGALG00000028063Gallus gallus
 LOXENSG00000113083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG0000003233454
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518532
Loxl3 / Q9Z175 / Lysyl oxidase homolog 3 / P58215* / lysyl oxidase like 3*ENSMUSG0000000069332
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420531
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG000000246709
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG000000263903
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG000000250443
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG000000220322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001695  Lysyl oxidase
 IPR013783  Immunoglobulin-like fold
 IPR019828  Lysyl oxidase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0048251 elastic fiber assembly IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: KitlSl-19J/KitlSl-19J
Genetic Background: C3HeB/FeJ

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-19J/KitlSl-19J
Genetic Background: C3HeB/FeJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-19J/KitlSl-19J
Genetic Background: C3HeB/FeJ

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0003907 decreased aorta elastin content "reduction in the physical amount of elastin in the aorta compared to the normal state" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0006049 semilunar valve insufficiency "the semilunar valves do not close tightly enough to prevent leakage." [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ae/ae
Genetic Background: (P x S)F1

 MP:0006083 abnormal vascular elastic tissue "malformation in the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008418 abnormal cutaneous elastic fiber morphology "any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0009868 abnormal descending thoracic aorta morphology "any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010471 supravalvar aortic stenosis "a narrowing, diffuse constriction or obstruction of the ascending aorta located just distal to the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxb2b370.2Clo/Loxb2b370.2Clo
Genetic Background: C57BL/6J-Loxb2b370.2Clo

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010997 decreased aorta wall thickness "decreased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
Show

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011034 impaired branching involved in respiratory bronchiole morphogenesis 
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Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

Allelic Composition: Loxtm1Soin/Loxtm1Soin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022098 Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*  / reaction
 ENSMUSG00000030116 Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*  / reaction
 ENSMUSG00000021186 Fbln5 / Q9WVH9 / Fibulin-5 / Q9UBX5*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000029675 Eln / P54320 / Elastin / P15502*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000060572 Mfap2 / microfibril associated protein 2 / P55001*  / reaction
 ENSMUSG00000053626 Tll1 / tolloid-like / O43897* / tolloid like 1*  / reaction






 

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