ENSMUSG00000000693


Mus musculus

Features
Gene ID: ENSMUSG00000000693
  
Biological name :Loxl3
  
Synonyms : Loxl3 / Lysyl oxidase homolog 3 / Q9Z175
  
Possible biological names infered from orthology : lysyl oxidase like 3 / P58215
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83034173
Gene end: 83052562
  
Corresponding Affymetrix probe sets: 10539263 (MoGene1.0st)   1418269_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098815
Ensembl peptide - ENSMUSP00000000707
NCBI entrez gene - 16950     See in Manteia.
MGI - MGI:1337004
RefSeq - NM_013586
RefSeq Peptide - NP_038614
swissprot - E9Q0X7
swissprot - Q9Z175
Ensembl - ENSMUSG00000000693
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LOXL3ENSG00000115318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Loxl4 / Q924C6 / Lysyl oxidase homolog 4 / Q96JB6* / lysyl oxidase like 4*ENSMUSG0000002518555
Loxl2 / P58022 / Lysyl oxidase homolog 2 / Q9Y4K0* / lysyl oxidase like 2*ENSMUSG0000003420555
Loxl1 / lysyl oxidase like 1 / Q08397*ENSMUSG0000003233422
Cd6 / Q61003 / T-cell differentiation antigen CD6 / P30203* / CD6 molecule*ENSMUSG0000002467018
Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*ENSMUSG0000002452917
Marco / Q60754 / Macrophage receptor MARCO / Q9UEW3* / macrophage receptor with collagenous structure*ENSMUSG0000002639010
Msr1 / P30204 / Macrophage scavenger receptor types I and II / P21757* / macrophage scavenger receptor 1*ENSMUSG0000002504410
Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*ENSMUSG000000220329


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR001695  Lysyl oxidase
 IPR017448  SRCR-like domain
 IPR019828  Lysyl oxidase, conserved site
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0018057 peptidyl-lysine oxidation IEA
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:1905590 fibronectin fibril organization IMP
 biological_processGO:2000329 negative regulation of T-helper 17 cell lineage commitment IMP
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0004720 protein-lysine 6-oxidase activity ISO
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0000098 abnormal vomer bone morphology "missing triangular flat bone of the nasal septum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0005227 abnormal vertebral body development "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Npytm1(cre)Zman/Npytm1(cre)Zman
Genetic Background: involves: 129/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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