Manteia - Molecule gene

ENSMUSG00000060572

Mus musculus

Features

Gene ID:	ENSMUSG00000060572

Biological name :	Mfap2

Synonyms :	Mfap2 / microfibril associated protein 2

Possible biological names infered from orthology :	P55001

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	D3
Gene start:	141010418
Gene end:	141015984

Corresponding Affymetrix probe sets:	10509901 (MoGene1.0st) 1417359_at (Mouse Genome 430 2.0 Array) 1447833_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000071868 Ensembl peptide - ENSMUSP00000132711 NCBI entrez gene - 17150 See in Manteia. MGI - MGI:99559 RefSeq - XM_006538615 RefSeq - NM_001161799 RefSeq - NM_008546 RefSeq - XM_006538612 RefSeq Peptide - NP_001155271 RefSeq Peptide - NP_032572 swissprot - Q99PM0 Ensembl - ENSMUSG00000060572

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mfap2	ENSDARG00000059367	Danio rerio
MFAP2	ENSGALG00000030647	Gallus gallus
MFAP2	ENSG00000117122	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*	ENSMUSG00000030116	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR003582	ShKT domain
IPR008673	Microfibril-associated glycoprotein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0048048	embryonic eye morphogenesis	IEA
biological_process	GO:0048050	post-embryonic eye morphogenesis	IEA
cellular_component	GO:0001527	microfibril	IEA

Pathways (from Reactome)

Pathway description

Elastic fibre formation

Molecules associated with elastic fibres

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Tbx20^tm1.2Rph/Tbx20^tm1.2Rph Genetic Background: B6.Cg-Tbx20^tm1.2Rph Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx20^tm1.2Rph/Tbx20^tm1.2Rph Genetic Background: B6.Cg-Tbx20^tm1.2Rph Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx20^tm1.2Rph/Tbx20^tm1.2Rph Genetic Background: B6.Cg-Tbx20^tm1.2Rph
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Mfsd2a^{tm1c(KOMP)Wtsi}/Mfsd2a^{tm1c(KOMP)Wtsi},Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mfsd2a^{tm1c(KOMP)Wtsi}/Mfsd2a^{tm1c(KOMP)Wtsi},Tg(Tek-cre)1Ywa/0 Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0002551	abnormal blood coagulation	"altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay,Psrs1^PL/J/Psrs1^PL/J Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2^tm1Bay Allelic Composition: Mfap2^tm1Mech/Mfap2⁺ Genetic Background: B6.129X1-Mfap2^tm1Mech
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay,Psrs1^PL/J/Psrs1^PL/J Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2^tm1Bay
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Tbx20^tm1.2Rph/Tbx20^tm1.2Rph Genetic Background: B6.Cg-Tbx20^tm1.2Rph
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0005606	increased bleeding time	"greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay,Psrs1^PL/J/Psrs1^PL/J Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2^tm1Bay
MP:0008121	increased myeloid dendritic cell number	"greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009285	increased gonadal fat pad weight	"greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009338	increased splenocyte number	"increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0010933	decreased trabecular bone connectivity density	"reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0010963	abnormal compact bone volume	"any anomaly in the amount of space occupied by compact bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mfap2^tm1Mech/Mfap2^tm1Mech,Mfap5^tm1Mech/Mfap5^tm1Mech Genetic Background: involves: 129X1/SvJ
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0013693	abnormal hemopoiesis	"any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0030007	abnormal bone marrow adipose tissue morphology	"any structural anomaly of the functionally distinct adipose depot that is located within the skeleton and has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases" [PMID:27094502]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N
MP:0030009	increased bone marrow adipose tissue amount	"increased quantity of the bone marrow fat-storing cells/tissue" [PMID:27094502]	Show Allelic Composition: Mfap2^{tm1a(KOMP)Wtsi}/Mfap2^{tm1a(KOMP)Wtsi} Genetic Background: involves: C57BL/6J * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000029675	Eln / P54320 / Elastin / P15502*	/ complex
ENSMUSG00000020522	Mfap3 / microfibril associated protein 3 / P55082*	/ complex / reaction
ENSMUSG00000017344	Vtn / P29788 / vitronectin / P04004*	/ complex / reaction
ENSMUSG00000024529	Lox / P28301 / Protein-lysine 6-oxidase / P28300* / lysyl oxidase*	/ reaction
ENSMUSG00000021186	Fbln5 / Q9WVH9 / Fibulin-5 / Q9UBX5*	/ complex
ENSMUSG00000042436	Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*	/ reaction / complex
ENSMUSG00000027204	Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*	/ complex / reaction
ENSMUSG00000024598	Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*	/ complex / reaction
ENSMUSG00000029163	Q99K41 / Emilin1 / Q9Y6C2* / elastin microfibril interfacer 1*	/ complex
ENSMUSG00000032334	Loxl1 / lysyl oxidase like 1 / Q08397*	/ reaction
ENSMUSG00000048222	C0HKD9 / C0HKD8 / Mfap1b / Microfibrillar-associated protein 1A / MFAP1* / P55081* / microfibril associated protein 1*	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr