ENSMUSG00000042436


Mus musculus

Features
Gene ID: ENSMUSG00000042436
  
Biological name :Mfap4
  
Synonyms : Mfap4 / Microfibril-associated glycoprotein 4 / Q9D1H9
  
Possible biological names infered from orthology : microfibril associated protein 4 / P55083
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 61485431
Gene end: 61488900
  
Corresponding Affymetrix probe sets: 10376778 (MoGene1.0st)   1424010_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038971
Ensembl peptide - ENSMUSP00000070848
NCBI entrez gene - 76293     See in Manteia.
MGI - MGI:1342276
RefSeq - XM_006534422
RefSeq - NM_029568
RefSeq Peptide - NP_083844
RefSeq Peptide - NP_001334474
swissprot - Q9D1H9
Ensembl - ENSMUSG00000042436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO203432.1ENSDARG00000115195Danio rerio
 mfap4ENSDARG00000090783Danio rerio
 MFAP4 (1 of many)ENSDARG00000090557Danio rerio
 si:ch1073-110a20.3ENSDARG00000096586Danio rerio
 si:zfos-2330d3.1ENSDARG00000038683Danio rerio
 wu:fj11g02ENSDARG00000038681Danio rerio
 zgc:173915ENSDARG00000089667Danio rerio
 zmp:0000001323ENSDARG00000094845Danio rerio
 MFAP4ENSG00000166482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684144
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683540
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693839
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874236
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989933
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230933
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746033
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354432
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898932
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410532
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146531


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0010712 regulation of collagen metabolic process IEA
 biological_processGO:0048251 elastic fiber assembly IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:0097435 supramolecular fiber organization IEA
 cellular_componentGO:0001527 microfibril IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0071953 elastic fiber IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0010937 increased total lung capacity "greater volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0011045 decreased lung elastance "reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000029163 Q99K41 / Emilin1 / Q9Y6C2* / elastin microfibril interfacer 1*  / reaction / complex
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / complex / reaction
 ENSMUSG00000029675 Eln / P54320 / Elastin / P15502*  / reaction / complex
 ENSMUSG00000060572 Mfap2 / microfibril associated protein 2 / P55001*  / reaction / complex
 ENSMUSG00000030116 Mfap5 / Q9QZJ6 / Microfibrillar-associated protein 5 / Q13361* / microfibril associated protein 5*  / reaction / complex






 

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