ENSMUSG00000039899


Mus musculus

Features
Gene ID: ENSMUSG00000039899
  
Biological name :Fgl2
  
Synonyms : Fgl2 / Fibroleukin / P12804
  
Possible biological names infered from orthology : fibrinogen like 2 / Q14314
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 21372642
Gene end: 21378374
  
Corresponding Affymetrix probe sets: 10519983 (MoGene1.0st)   1421854_at (Mouse Genome 430 2.0 Array)   1421855_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046131
NCBI entrez gene - 14190     See in Manteia.
MGI - MGI:103266
RefSeq - NM_008013
RefSeq Peptide - NP_032039
swissprot - P12804
swissprot - Q544K3
Ensembl - ENSMUSG00000039899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgl2aENSDARG00000019861Danio rerio
 fgl2bENSDARG00000019686Danio rerio
 FGL2ENSGALG00000008306Gallus gallus
 FGL2ENSG00000127951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898928
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230928
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146528
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746027
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684126
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874225
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693825
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354424
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410523
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683523
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243621


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR033083  Fibroleukin
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019835 cytolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0008233 peptidase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgl2tm1Pam/Fgl2tm1Pam
Genetic Background: B6.129X1-Fgl2tm1Pam

Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgl2tm1Pam/Fgl2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgl2tm1Pam/Fgl2tm1Pam
Genetic Background: B6.129X1-Fgl2tm1Pam

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Fgl2tm1Pam/Fgl2tm1Pam
Genetic Background: B6.129X1-Fgl2tm1Pam

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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