ENSMUSG00000027460


Mus musculus

Features
Gene ID: ENSMUSG00000027460
  
Biological name :Angpt4
  
Synonyms : Angiopoietin-4 / Angpt4 / Q9WVH6
  
Possible biological names infered from orthology : Q9Y264
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 151911210
Gene end: 151945337
  
Corresponding Affymetrix probe sets: 10477042 (MoGene1.0st)   1450325_at (Mouse Genome 430 2.0 Array)   1455427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028955
NCBI entrez gene - 11602     See in Manteia.
MGI - MGI:1336887
RefSeq - NM_009641
RefSeq Peptide - NP_033771
swissprot - Q3V0P7
swissprot - Q9WVH6
Ensembl - ENSMUSG00000027460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt4ENSDARG00000076787Danio rerio
 ANGPT4ENSGALG00000040755Gallus gallus
 ANGPT4ENSG00000101280Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230946
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146544
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410525
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354424
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874224
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989923
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898923
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684123
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683519
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693818
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243618


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028845  Angiopoietin-4
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007492 endoderm development TAS
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048014 Tie signaling pathway TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding TAS
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex






 

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