ENSMUSG00000031465


Mus musculus

Features
Gene ID: ENSMUSG00000031465
  
Biological name :Angpt2
  
Synonyms : Angiopoietin-2 / Angpt2 / O35608
  
Possible biological names infered from orthology : O15123
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.3
Gene start: 18690263
Gene end: 18741562
  
Corresponding Affymetrix probe sets: 10577315 (MoGene1.0st)   1448831_at (Mouse Genome 430 2.0 Array)   1459636_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033846
NCBI entrez gene - 11601     See in Manteia.
MGI - MGI:1202890
RefSeq - NM_007426
RefSeq Peptide - NP_031452
swissprot - B9EHQ4
swissprot - O35608
Ensembl - ENSMUSG00000031465
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt2aENSDARG00000014946Danio rerio
 ANGPT2ENSGALG00000036189Gallus gallus
 ANGPT2ENSG00000091879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230959
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746045
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354427
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410526
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874225
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989924
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898921
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684120
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683520
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243618
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028844  Angiopoietin-2
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001974 blood vessel remodeling TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007492 endoderm development TAS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IDA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0030097 hemopoiesis TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0045765 regulation of angiogenesis TAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048014 Tie signaling pathway TAS
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0050928 negative regulation of positive chemotaxis ISO
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072012 glomerulus vasculature development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Skor2tm1Yono/Skor2tm1Yono
Genetic Background: involves: 129 * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005257 abnormal intraocular pressure "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0011960 abnormal eye anterior chamber depth "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

 MP:0012684 abnormal pleural cavity morphology "any structural anomaly of the potential space between the two pleurae (visceral and parietal) of the lungs; the pleural cavity, with its associated pleurae, aids optimal functioning of the lungs during breathing; it normally contains a thin film of serous fluid which lubricates the opposed pleural membranes so that they can glide smoothly against one another during ventilation" [MGI:anna]
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Allelic Composition: Prkcbtm1Tara/Prkcb+
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex






 

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