ENSMUSG00000022309


Mus musculus

Features
Gene ID: ENSMUSG00000022309
  
Biological name :Angpt1
  
Synonyms : Angiopoietin-1 / Angpt1 / O08538
  
Possible biological names infered from orthology : Q15389
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 42424723
Gene end: 42676977
  
Corresponding Affymetrix probe sets: 10428376 (MoGene1.0st)   1421441_at (Mouse Genome 430 2.0 Array)   1439066_at (Mouse Genome 430 2.0 Array)   1457381_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022921
NCBI entrez gene - 11600     See in Manteia.
MGI - MGI:108448
RefSeq - XM_006520323
RefSeq - NM_001286062
RefSeq - NM_009640
RefSeq Peptide - NP_033770
RefSeq Peptide - NP_001272991
swissprot - O08538
Ensembl - ENSMUSG00000022309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt1ENSDARG00000030364Danio rerio
 ANGPT1ENSGALG00000029983Gallus gallus
 ANGPT1ENSG00000154188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146559
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746047
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354427
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410525
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898924
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989924
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874224
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684121
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683520
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693819
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243619


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028843  Angiopoietin-1
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis TAS
 biological_processGO:0001570 vasculogenesis TAS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IDA
 biological_processGO:0003160 endocardium morphogenesis TAS
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development TAS
 biological_processGO:0010595 positive regulation of endothelial cell migration TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030210 heparin biosynthetic process IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031589 cell-substrate adhesion IDA
 biological_processGO:0032680 regulation of tumor necrosis factor production IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0042308 negative regulation of protein import into nucleus IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IGI
 biological_processGO:0043393 regulation of protein binding IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0048014 Tie signaling pathway TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis TAS
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072012 glomerulus vasculature development IDA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000446 regulation of macrophage migration inhibitory factor signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding TAS
 molecular_functionGO:0030971 receptor tyrosine kinase binding ISO


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005257 abnormal intraocular pressure "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.2Seq,Tg(Pdgfrb-cre)#Rha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Angpt1tm1.2Seq/Angpt1tm1.2Seq,Kdrtm2.1Jrt/Kdr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011960 abnormal eye anterior chamber depth "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0012049 increased susceptilbility to retinal ischemic injury "increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina" [MGI:csmith]
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae

 MP:0012066 decreased astrocyte number "reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith]
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Allelic Composition: Angpt1tm1.1Yona/Angpt1tm1.1Yona,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Angpt1tm2Sato/Angpt1tm2Sato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000022102 Dok2 / O70469 / Docking protein 2 / O60496*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000026888 Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr