ENSMUSG00000024241


Mus musculus

Features
Gene ID: ENSMUSG00000024241
  
Biological name :Sos1
  
Synonyms : Q62245 / Son of sevenless homolog 1 / Sos1
  
Possible biological names infered from orthology : Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E3
Gene start: 80393752
Gene end: 80480453
  
Corresponding Affymetrix probe sets: 10453141 (MoGene1.0st)   1421884_at (Mouse Genome 430 2.0 Array)   1421885_at (Mouse Genome 430 2.0 Array)   1421886_at (Mouse Genome 430 2.0 Array)   1431311_at (Mouse Genome 430 2.0 Array)   1434389_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067786
NCBI entrez gene - 20662     See in Manteia.
MGI - MGI:98354
RefSeq - NM_009231
RefSeq Peptide - NP_033257
swissprot - Q62245
Ensembl - ENSMUSG00000024241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sos1ENSDARG00000100503Danio rerio
 SOS1ENSGALG00000039450Gallus gallus
 SOS1ENSG00000115904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sos2 / Q02384 / Son of sevenless homolog 2 / Q07890* / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSMUSG0000003480169
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984417
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170812
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235612
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG0000002648211
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682111
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG0000004014610
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413549
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388317
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265947


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IGI
 biological_processGO:0001942 hair follicle development IGI
 biological_processGO:0002260 lymphocyte homeostasis IGI
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003209 cardiac atrium morphogenesis IMP
 biological_processGO:0003344 pericardium morphogenesis IMP
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IMP
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007296 vitellogenesis IMP
 biological_processGO:0033081 regulation of T cell differentiation in thymus IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042129 regulation of T cell proliferation IGI
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction TAS
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0061029 eyelid development in camera-type eye IGI
 biological_processGO:0061384 heart trabecula morphogenesis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904693 midbrain morphogenesis IMP
 biological_processGO:2000973 regulation of pro-B cell differentiation IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SOS-mediated signalling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
Activated NTRK2 signals through FRS2 and FRS3
Interleukin receptor SHC signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb1tm1Kwi/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-v/Kit+
Genetic Background: involves: C57BL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Sos1tm1.1Les/Sos1tm1.1Les,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Sos1tm1.1Les/Sos1tm1.1Les,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005099 abnormal ciliary body morphology "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Sos1tm1.2Rak/Sos1+
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sos1tm1Dlb/Sos1tm1Dlb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sos1tm1.2Rak/Sos1tm1.2Rak
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011697 vacuolated lens "fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSMUSG00000020312 Shc2 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / SHC adaptor protein 2*  / complex / reaction
 ENSMUSG00000018916 Csf2 / P01587 / Granulocyte-macrophage colony-stimulating factor / P04141* / colony stimulating factor 2*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000021448 Shc3 / Q61120 / src homology 2 domain-containing transforming protein C3 / Q92529* / SHC adaptor protein 3*  / reaction / complex
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / reaction / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000040751 Lat2 / Q9JHL0 / Linker for activation of T-cells family member 2 / Q9GZY6*  / reaction / complex
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction / complex
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000036117 Il5 / P04401 / Interleukin-5 / P05113*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction / complex
 ENSMUSG00000027303 Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / reaction / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / complex / reaction
 ENSMUSG00000038546 P69566 / Ranbp9 / Ran-binding protein 9 / Q96S59*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / reaction / complex
 ENSMUSG00000042817 Flt3 / fms related tyrosine kinase 3 / P36888*  / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex / reaction
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000110206 Flt3l / P49772 / Fms-related tyrosine kinase 3 ligand / FLT3LG* / P49771*  / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000068758 Il3ra / P26952 / Interleukin-3 receptor subunit alpha / P26951*  / reaction / complex
 ENSMUSG00000071713 Csf2rb / P26955 / Mus musculus colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (Csf2rb), transcript variant 1, mRNA. / P32927* / colony stimulating factor ...  / complex / reaction
 ENSMUSG00000059326 Csf2ra / Q00941 / Granulocyte-macrophage colony-stimulating factor receptor subunit alpha / P15509* / colony stimulating factor 2 receptor alpha subunit*  / reaction / complex
 ENSMUSG00000071714 P26954 / Csf2rb2 / Interleukin-3 receptor class 2 subunit beta / CSF2RB* / P32927* / colony stimulating factor 2 receptor beta common subunit*  / complex / reaction
 ENSMUSG00000005364 Il5ra / P21183 / Interleukin-5 receptor subunit alpha / Q01344*  / reaction / complex






 

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