ENSMUSG00000034116


Mus musculus

Features
Gene ID: ENSMUSG00000034116
  
Biological name :Vav1
  
Synonyms : P27870 / Vav1 / vav 1 oncogene
  
Possible biological names infered from orthology : P15498 / vav guanine nucleotide exchange factor 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 57279100
Gene end: 57328031
  
Corresponding Affymetrix probe sets: 10446253 (MoGene1.0st)   1422932_a_at (Mouse Genome 430 2.0 Array)   1440300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005889
Ensembl peptide - ENSMUSP00000108491
Ensembl peptide - ENSMUSP00000126694
NCBI entrez gene - 22324     See in Manteia.
MGI - MGI:98923
RefSeq - NM_001163816
RefSeq - NM_001163815
RefSeq - NM_011691
RefSeq Peptide - NP_035821
RefSeq Peptide - NP_001157287
RefSeq Peptide - NP_001157288
swissprot - Q8VDU4
swissprot - P27870
swissprot - Q3U9E2
swissprot - E9PXI0
Ensembl - ENSMUSG00000034116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VAV1ENSG00000141968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372158
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962153
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962118
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380016
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896016
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199015
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248915
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151114
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113313
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750912
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000980  SH2 domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003096  Smooth muscle protein/calponin
 IPR011993  PH-like domain superfamily
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR028530  Protein vav1
 IPR035729  VAV1 protein, second SH3 domain
 IPR035730  VAV1 protein, first SH3 domain
 IPR035879  VAV1, SH2 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IGI
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007229 integrin-mediated signaling pathway IGI
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0030217 T cell differentiation TAS
 biological_processGO:0030593 neutrophil chemotaxis IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IGI
 biological_processGO:0045785 positive regulation of cell adhesion IGI
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IGI
 biological_processGO:0072593 reactive oxygen species metabolic process IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IGI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
CD28 dependent Vav1 pathway
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
VEGFR2 mediated vascular permeability
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0002407 abnormal double-negative T cell "anomalous structure, development, or number of the subset of T cells found in the thymus that express neither CD4 nor CD8" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvJae * C57BL/10 * C57BR/cd

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: C.129S2-Vav1tm1Tyb

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Anu/Dock2m1Anu
Genetic Background: C57BL/6JAnu-Dock2m1Anu

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * 129S8/SvEv

Allelic Composition: Vav1tm2Tyb/Vav1tm2Tyb
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Rag1tm1Bal/Rag1tm1Bal,Vav1tm2Tyb/Vav1tm2Tyb,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Tnr/Vav2tm1Tnr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0008686 abnormal interleukin-2 secretion "anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd,Vav2tm1Kdf/Vav2tm1Kdf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010131 increased DN2 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Vav1tm4Tyb/Vav1tm4Tyb
Genetic Background: either: 129S8.129S4-Vav1tm4Tyb or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: either: (involves: 129S4/SvJae * 129S8/SvEv) or (involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd)

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb,Vav2tm1Kdf/Vav2tm1Kdf,Vav3tm1Swat/Vav3tm1Swat
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ighmtm1Che/Ighmtm1Che
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / reaction / complex
 ENSMUSG00000033220 Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*  / reaction
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / complex
 ENSMUSG00000030724 Cd19 / P25918 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P15391* / CD19 molecule*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000073982 Rhog / P84096 / ras homolog family member G / P84095*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000026012 Cd28 / P31041 / T-cell-specific surface glycoprotein CD28 / P10747* / CD28 molecule*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000022901 Cd86 / P42082 / T-lymphocyte activation antigen CD86 / P42081* / CD86 molecule*  / reaction / complex
 ENSMUSG00000075122 Cd80 / Q00609 / T-lymphocyte activation antigen CD80 / P33681* / CD80 molecule*  / reaction / complex






 

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