ENSMUSG00000031133


Mus musculus

Features
Gene ID: ENSMUSG00000031133
  
Biological name :Arhgef6
  
Synonyms : Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6
  
Possible biological names infered from orthology : Q15052
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A6
Gene start: 57231485
Gene end: 57338729
  
Corresponding Affymetrix probe sets: 10604713 (MoGene1.0st)   1429012_at (Mouse Genome 430 2.0 Array)   1442292_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033468
Ensembl peptide - ENSMUSP00000110383
Ensembl peptide - ENSMUSP00000134851
Ensembl peptide - ENSMUSP00000135475
NCBI entrez gene - 73341     See in Manteia.
MGI - MGI:1920591
RefSeq - XM_006528316
RefSeq - NM_152801
RefSeq - XM_006528313
RefSeq - XM_006528314
RefSeq - XM_006528315
RefSeq Peptide - NP_690014
swissprot - H3BJ53
swissprot - H3BKQ0
swissprot - F6WMJ3
swissprot - A2AFJ8
Ensembl - ENSMUSG00000031133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef6ENSDARG00000006683Danio rerio
 Q5ZLR6ENSGALG00000006439Gallus gallus
 Q15052ENSG00000129675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151153
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380018
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962116
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248916
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199015
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411614
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372114
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896014
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962113
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750912
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR003096  Smooth muscle protein/calponin
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain
 IPR035788  Rho guanine nucleotide exchange factor 6, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf1tm1.2Sabw/Csf1tm1.2Sabw
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022438 Parvb / Q9ES46 / parvin, beta / Q9HBI1*  / complex / reaction






 

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