ENSMUSG00000048960


Mus musculus

Features
Gene ID: ENSMUSG00000048960
  
Biological name :Prex2
  
Synonyms : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Prex2 / Q3LAC4
  
Possible biological names infered from orthology : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q70Z35
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A2
Gene start: 10993465
Gene end: 11303681
  
Corresponding Affymetrix probe sets: 10344837 (MoGene1.0st)   1432047_at (Mouse Genome 430 2.0 Array)   1436569_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027056
Ensembl peptide - ENSMUSP00000140863
Ensembl peptide - ENSMUSP00000140788
Ensembl peptide - ENSMUSP00000140621
Ensembl peptide - ENSMUSP00000140580
NCBI entrez gene - 109294     See in Manteia.
MGI - MGI:1923385
RefSeq - XM_006495441
RefSeq - NM_001033636
RefSeq - NM_029525
RefSeq Peptide - NP_001028808
RefSeq Peptide - NP_083801
swissprot - A0A087WS21
swissprot - A0A087WRV5
swissprot - A0A087WRD8
swissprot - A0A087WRG8
swissprot - Q3LAC4
Ensembl - ENSMUSG00000048960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex2ENSDARG00000071692Danio rerio
 PREX2ENSGALG00000042354Gallus gallus
 PREX2ENSG00000046889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962157
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG000000256569
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG000000096219
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG000000375099
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG000000219909
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG000000238008
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG000000337218
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG000000341168
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG000000315117
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG000000311337
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG000000024897


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR037367  PREX2, DEP domain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+,Myf5tm1.1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg,Tg(Pcp2-EGFP)2Yuza/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / complex / reaction






 

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