ENSMUSG00000013663


Mus musculus

Features
Gene ID: ENSMUSG00000013663
  
Biological name :Pten
  
Synonyms : O08586 / phosphatase and tensin homolog / Pten
  
Possible biological names infered from orthology : P60484
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 32757497
Gene end: 32826160
  
Corresponding Affymetrix probe sets: 10462521 (MoGene1.0st)   1422553_at (Mouse Genome 430 2.0 Array)   1438454_at (Mouse Genome 430 2.0 Array)   1450655_at (Mouse Genome 430 2.0 Array)   1454722_at (Mouse Genome 430 2.0 Array)   1455728_at (Mouse Genome 430 2.0 Array)   1457493_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000013807
NCBI entrez gene - 19211     See in Manteia.
MGI - MGI:109583
RefSeq - NM_008960
RefSeq - XM_006526769
RefSeq Peptide - NP_032986
swissprot - O08586
Ensembl - ENSMUSG00000013663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptenaENSDARG00000071018Danio rerio
 ptenbENSDARG00000056623Danio rerio
 PTENENSGALG00000003634Gallus gallus
 PTENENSG00000171862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG0000003148131
Tns1 / tensin 1 / Q9HBL0*ENSMUSG0000005532229
Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*ENSMUSG0000002042226
Tns2 / Q8CGB6 / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q63HR2* / tensin 2*ENSMUSG0000003700326
Gak / cyclin-G-associated kinase isoform 3 / O14976* / cyclin G associated kinase*ENSMUSG0000006223422
Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*ENSMUSG0000002852820
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG000000176078


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR017361  Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0002902 regulation of B cell apoptotic process IMP
 biological_processGO:0006470 protein dephosphorylation ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007270 neuron-neuron synaptic transmission IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007613 memory IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0032286 central nervous system myelin maintenance IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032535 regulation of cellular component size IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033032 regulation of myeloid cell apoptotic process IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0033555 multicellular organismal response to stress IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0036294 cellular response to decreased oxygen levels IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045792 negative regulation of cell size IMP
 biological_processGO:0046621 negative regulation of organ growth IMP
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0046855 inositol phosphate dephosphorylation ISS
 biological_processGO:0046856 phosphatidylinositol dephosphorylation ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048679 regulation of axon regeneration IGI
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050771 negative regulation of axonogenesis IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051548 negative regulation of keratinocyte migration IEA
 biological_processGO:0051726 regulation of cell cycle IGI
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISO
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISO
 biological_processGO:0060024 rhythmic synaptic transmission IMP
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060074 synapse maturation IMP
 biological_processGO:0060134 prepulse inhibition IMP
 biological_processGO:0060179 male mating behavior IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0060341 regulation of cellular localization IMP
 biological_processGO:0060736 prostate gland growth IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071257 cellular response to electrical stimulus IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0090071 negative regulation of ribosome biogenesis IMP
 biological_processGO:0090344 negative regulation of cell aging IMP
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential IMP
 biological_processGO:0097105 presynaptic membrane assembly IMP
 biological_processGO:0097107 postsynaptic density assembly IMP
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903690 negative regulation of wound healing, spreading of epidermal cells IEA
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000272 negative regulation of signaling receptor activity IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IMP
 biological_processGO:2000808 negative regulation of synaptic vesicle clustering IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0035749 myelin sheath adaxonal region IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IMP
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004438 phosphatidylinositol-3-phosphatase activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISO
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISO
 molecular_functionGO:1990381 ubiquitin-specific protease binding ISO
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Flcntm1Btt/Flcntm1Btt,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * ICR

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000288 abnormal pericardium morphology "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]
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Allelic Composition: Ptentm2Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Ptentm1Engc/Pten+
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi,Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Pcsk9tm1.2Prat/Pcsk9tm1.2Prat
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm1Hwu/Ptentm1Hwu,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000621 salivary adenocarcinoma "malignant neoplasm of the secreting cells of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Rps/Pten+,RictorGt(RRR347)Byg/Rictor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Rps/Ptentm1Rps
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CD2-icre)4Kio/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KRT14-cre)8Brn/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000858 altered metastatic potential 
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: FVB/N

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: FVB/N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: f/f+,KitW/Kit+
Genetic Background: FL/1Re-KitW/J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Ptentm2Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Ptentm2Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Pten+,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rapgef2tm1.2Hous/Rapgef2tm1.2Hous
Genetic Background: involves: 129S1/Sv

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Rapgef2tm1.2Hous/Rapgef2tm1.2Hous
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001133 impaired luteal cell differentiation "abnormal development of the cells of the corpus luteum of the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

 MP:0001138 abnormal cervical squamous epithelium "malformation of the scaly epithelial layer of the cervix" [MGI:tc, J:54637]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)8113ANg/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)8113ANg/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3catm1Jjz/Pik3catm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3catm1Jjz/Pik3catm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scn8am10J/Scn8am10J
Genetic Background: FVB/NJ-Scn8am10J/GrsrCx

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Zeb1tm1.1Ajg/Zeb1Tw
Genetic Background: B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001272 increased metastatic potential 
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Pten+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(KLK3-cre)13Saa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1.1Mro/Pten+,Sdhbtm1.2Ics/Sdhb+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Ptentm1.1Mro/Pten+
Genetic Background: Not Specified

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Rdp/Ptentm1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb8tm4.1(cre/Esr1*)Mrc/Hoxb8tm4.1(cre/Esr1*)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps/Nci

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps/Nci

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

Allelic Composition: MtorGt(OST92090)Lex/Mtor+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Mlst8tm1Lex/Mlst8+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: FVB/N

Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1.2Mwst/Ptentm1.2Mwst
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Ptentm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Ptentm2.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Kif3a2a/Kif3a2a
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001711 abnormal placenta 
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Kif3a2a/Kif3a2a
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mefvtm5.1(MEFV)Chae/Mefvtm6Chae
Genetic Background: B6.129S6-Mefvtm5.1(MEFV)Chae/Mefvtm6Chae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(MMTVneu)202Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: FVB/N

Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001885 mammary ductal hyperplasia 
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pik3catm1Jjz/Pik3catm1Jjz,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Rapgef2tm1.2Hous/Rapgef2tm1.2Hous
Genetic Background: involves: 129S1/Sv

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: EdaTa-23H/EdaTa-23H
Genetic Background: C3H101H-EdaTa-23H/H

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Camk2a-cre)T50Stl/0,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Prpf8tm1.1Eap/Prpf8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2tm1Kwhi/Ccm2tm1.1Kwhi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002015 epithelioid cysts "abnormal membraneous sacs appearing in an epithelium" [J:51296]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm2Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm2Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm2Mak/Ptentm2Mak,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002030 neurofibrosarcoma "malignant neoplasm of fibrous tissue of the nervous system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Pten+,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Thl/Trp53tm1Thl,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KRT14-cre)8Brn/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Sdhbtm1.1Ics/Sdhbtm1.1Ics,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

Allelic Composition: Ptentm1.1Mro/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Sdhbtm1.1Ics/Sdhb+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Sdhbtm1.1Ics/Sdhbtm1.2Ics,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB

Allelic Composition: Ptentm1Mro/Pten+,Sdhbtm1.1Ics/Sdhb+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129S2/SvPas * FVB

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Eif4etm1.1Lfur/Eif4etm1.1Lfur,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rps/Pten+,RictorGt(RRR347)Byg/Rictor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm6Keb/Acetm6Keb
Genetic Background: involves: 129 * C57BL/6 * CD-1

Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Ptentm1Rps
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Thl/Trp53tm1Thl,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(KRT14-cre)8Brn/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Hwu/Ptentm1Hwu,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(KLK3-cre)13Saa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Ptentm1.2Mwst/Ptentm1.2Mwst
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Ptentm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Ptentm2.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Ptentm1Engc/Pten+
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0002324 abnormal blood-air barrier "anomaly in the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn3tm4.1Sud/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002635 reduced sensorimotor gating 
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Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Pten+,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002676 uterine hyperplasia "increased size of the uterus due to increased cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Pten+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Lepob/Lepob,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apctm1Tno/Apc+,Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0003498 thyroid hyperplasia 
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0003502 increased activity of thyroid 
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Foxo3tm1Rdp/Foxo3tm1Rdp,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0003574 abnormal oviduct morphology "malformation of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003597 epididymal cystademona 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Thl/Trp53tm1Thl,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0003608 prostate inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0003630 abnormal urothelium "malformation of the mucus lining in organs of the urinary tract, consisting in the bladder of three to seven cell layers" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95622]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Pten+,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003752 oral papilloma "benign epithelial tumor of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps/Nci

 MP:0003869 ectopic cartilage "positional abnormality of cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003875 abnormal hair follicle regresssion "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Ptentm1Rps
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnm2tm1.1Ics/Dnm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Kif3a2a/Kif3a2a
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004556 enlarged allantois "increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129 * FVB/NCr

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Inhbbtm1Grid/Inhbbtm1Grid
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zeb1tm1.1Ajg/Zeb1Tw
Genetic Background: B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0004848 abnormal liver size "anomaly in the average size of the liver " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0004868 endometrial carcinoma "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004906 enlarged uterus 
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps/Nci

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zeb1tm1.1Ajg/Zeb1Tw
Genetic Background: B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004944 abnormal B cell negative selection "any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(GFAP-TAg121)1Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0004958 enlarged prostate "increased size of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)8113ANg/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0004961 increased prostate weight "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0004962 decreased prostate weight "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0004967 abnormal kidney epithelium morphology "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0005133 increased luteinizing hormone level "higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0,Tg(Myh6-Pik3ca)1Siz/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnm2tm1.1Ics/Dnm2+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: involves: C57BL/6 * CB17

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1.2Mwst/Ptentm1.2Mwst
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Ptentm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Ptentm2.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Camk2a-cre)T50Stl/0,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005284 increased saturated fatty acid level "greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain contains only single carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Dicer1tm1Tara/Dicer1tm1Tara,Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zeb1tm1.1Ajg/Zeb1Tw
Genetic Background: B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005470 increased thyroxine level "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

 MP:0005488 bronchial epithelial hyperplasia "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0005490 Clara cell hyperplasia "increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:48446]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0005603 neuron hypertrophy "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Tg(T-cre/ERT2)1Lwd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

 MP:0006078 abnormal nipple morphology "malformation of the erectile protuberance at the tip of the mammary gland" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92627]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Col2a1-cre)1Xya/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0006422 mammary adenoacanthoma "higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: ApcMin/Apc+,Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Camk2a-cre)T50Stl/0,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * CBA

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008413 decreased cellular sensitivity to oxidative stress "reduced incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008490 enlarged dorsal root ganglion "increased size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Cnp-EGFR)10Nrat/0,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(Pcp2-cre)756Mro/0
Genetic Background: involves: FVB/N

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Clec4etm1Tks/Clec4etm1Tks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Scgb1a1tm1.1(cre)Fjd/Scgb1a1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0008715 lung small cell carcinoma "an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm" [MESH:C04.557.465.625.650.240.390]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0008717 lung squamous cell carcinoma "a lung carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008728 increased memory B cell number "greater number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008746 abnormal peripheral B cell anergy "any anomaly of the processes of B cell anergy that occur outside the bone marrow" [GO:0002453]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn,Tg(IghelMD4)4Ccg/0,Tg(ML5sHEL)5Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1.1Mro/Ptentm1.1Mro
Genetic Background: involves: BALB/cJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Ptentm1.1Mwst/Pten+,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0008780 pancreatic acinar cell carcinoma "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0008914 enlarged cerebellum "increased size of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Mro/Ptentm1Mro,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0009053 abnormal anal canal morphology "any structural abnormality in the terminal portion of the alimentary canal, which begins at the anorectal junction, where the rectal ampulla abruptly narrows as the alimentary canal pierces the pelvic diaphragm (levator ani), and ends at the anal verge, when the anoderm that lines the lower anal canal changes to hairy perianal skin; surrounded by the internal and external anal sphincters" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009105 penis prolapse "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * DBA

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: B6.129S1-Ptentm1Rps

Allelic Composition: Ptentm1Rps/Pten+,Slc6a4tm1Kpl/Slc6a4+
Genetic Background: B6.129-Slc6a4tm1Kpl Ptentm1Rps

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009159 increased pancreatic acinar cell number "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Akt1tm1Nhy/Akt1+,Akt2tm1Rsg/Akt2tm1Rsg,Ptentm1Ppp/Pten+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009216 abnormal peritoneum morphology "any structural abnormality of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hspa5tm1Alee/Hspa5+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/?
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Terttm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/N

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Ptentm1.1Hwu/Pten+,Tmprss2tm1.1(ERG)Sho/Tmprss2tm1.1(ERG)Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1.1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Del(16Tmprss2-Erg)1Sho/Del(16Tmprss2-Erg)1Sho,Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(KLK3-cre)13Saa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Pten+,Tg(ARR2/Pbsn-FGF8)3Prb/0,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Hspa5tm1Alee/Hspa5+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/?
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Artm1Verh/Y,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cop1tm2.1Vmd/Cop1tm2.1Vmd,Tg(Pbsn-cre)4Prb/0
Genetic Background: B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm1Rdp/Tert+,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Smad4tm1Rdp/Smad4tm1Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Rdp/Ptentm1Rdp,Terttm3Rdp/Terttm3Rdp,Trp53tm1Brn/Trp53tm1Brn,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ergtm1.1Sho/Ergtm1.1Sho,Ptentm1Hwu/Ptentm1Hwu,Tmprss2tm3Sho/Tmprss2tm3Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(KLK3-cre)13Saa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(JAG1)Xin/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

 MP:0009223 uterus carcinoma 
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Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

 MP:0009277 brain tumor "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009318 splenic marginal zone lymphoma "neoplasm arising from the B cell-rich zones of the spleen" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Gdf9-icre)5092Coo

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0009469 skin hamartoma "a benign formation of a mass of tissue of disproportionate size and distribution in the skin, but composed of an overgrowth of mature cells and tissues that normally occur in this tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3catm1Jjz/Pik3catm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

Allelic Composition: Pik3cbtm1Jjz/Pik3cbtm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0009505 abnormal mammary gland lobule morphology "any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0009508 mammary gland ductal carcinoma "higher than normal incidence of malignant tumors of the ducts of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009550 urinary bladder carcinoma "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Hwu/Ptentm1Hwu,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0009551 urinary bladder transitional cell carcinoma "a malignant neoplasm of the transitional epithelial layer of the urinary bladder" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Thl/Trp53tm1Thl,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+,Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0009612 thick epidermis suprabasal layer 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Errfi1)Jwj/?,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0009715 thick epidermis stratum basale "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pik3catm1Jjz/Pik3catm1Jjz,Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr

 MP:0009734 abnormal prostate gland duct morphology "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rictortm1.1Mgn/Rictortm1.1Mgn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0009737 prostate gland cysts "benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Pten+,Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009738 enlarged prostate gland anterior lobe "increased size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12645922, PMID:3308446]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0009971 decreased hippocampus pyramidal cell number "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010050 hypermyelination "anomaly in the process by which myelin sheaths are formed and maintained around neurons resulting in increased myelin formation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Plp1-cre/ERT2)1Ueli/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0010160 increased oligodendrocyte number "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0010171 abnormal centroacinar cell of Langerhans morphology "any structural anomaly of cells that line the pancreatic ducts that secrete mucins and an aqueous bicarbonate solution under stimulation by the hormone secretin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010204 abnormal astrocyte apoptosis "change in the timing or the number of astrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(GFAP-TAg121)1Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

 MP:0010273 increased classified tumor incidence "greater than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0010274 increased organ/body region tumor incidence "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

 MP:0010275 increased melanoma incidence "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Ptentm1Rps/Ptentm1Rps,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0010277 increased astrocytoma incidence "greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Tyj/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Nf1tm1Par/Nf1+,Ptentm1Hwu/Pten+,Trp53tm1Elee/Trp53+,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(GFAP-TAg121)1Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0010278 increased glioma incidence "greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Nes-cre/ERT2,-ALPP)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010281 increased nervous system tumor incidence "greater than the expected number of tumors originating in the nervous system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010286 increased plasmacytoma incidence "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1Hwu/Pten+,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: FVB/N

Allelic Composition: Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(MMTVneu)202Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: FVB/N

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Pten+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Gfap-cre)1Sbk/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010312 increased oligodendroglioma incidence "greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptentm1Mro/Ptentm1Mro,Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor

 MP:0010314 increased neurofibroma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0010315 increased cholangiocarcinoma incidence "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Rdp/Ptentm1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm2.1Ppp/Pten+,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pkn3tm1.1Mrl/Pkn3tm1.1Mrl,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Pkn3tm1.1Mrl/Pkn3+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0010346 increased thyroid carcinioma incidence "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

Allelic Composition: Krastm4Tyj/Kras+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Krastm4Tyj Ptentm2.1Ppp Tg(Tpo-cre)1Shk

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: 129.Cg-Trp53tm1Brn Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Ppp/Ptentm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)8113ANg/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Trp53tm1Thl/Trp53tm1Thl,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ptentm1Mro/Pten+,Tg(KLK3-cre)D4Trp/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm1Ppp/Pten+,Tg(Pbsn-TAg)15Tvd/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm2(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Ptentm2.1Ppp/Pten+,Spry1tm1Jdli/Spry1tm1.1Jdli,Spry2tm1Mrt/Spry2tm1.1Mrt,Tg(Osr1-cre)4Mrt/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1tm1Mms,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(KLK3-cre)13Saa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010364 increased fibroadenoma incidence "greater than the expected number of a benign mammary gland tumor composed of both fibrous tissue and glandular tissue, in a specific population in a given time period" [CDR:523438 "http://www.cancer.gov/dictionary/?CdrID=523438"]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S4/SvJae

 MP:0010367 increased spindle cell carcinoma incidence "greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0010384 increased renal carcinoma incidence "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0010388 abnormal Bergmann glial cell differentiation "abnormal formation of the astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0010688 hair follicle outer rooth sheath hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

 MP:0010690 thick hair follicle outer rooth sheath "increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010727 increased glioblastoma incidence "greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698 "http://www.cancer.gov/dictionary/?CdrID=45698"]
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Allelic Composition: Ptentm1Rdp/Pten+,Trp53tm1Brn/Trp53tm1Brn,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0010827 small lung saccule "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0010829 increased bronchioalveolar stem cell number 
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0010910 bronchiolar epithelial hyperplasia "increased size, often due to increased epithelial cell number, of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0010915 increased solitary pulmonary neuroendocrine cell number "increased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010918 abnormal pulmonary neuroendocrine bodies "any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zeb1tm1.1Ajg/Zeb1Tw
Genetic Background: B6.Cg-Zeb1tm1.1Ajg/Zeb1Tw

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: B6.Cg-Ptentm1Hwu Tg(Nkx2-1-cre)2Sand

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(KRT14-cre)#Smr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ptentm1.2Mwst/Ptentm1.2Mwst
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Ptentm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Ptentm2.1Gle
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Ptentm1Hwu/Ptentm1Hwu,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Ptentm1Rps
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptenm1un/Ptenm1un
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Ptentm1.1Hwu/Ptentm1.1Hwu
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Foxo1tm1.1Rdp/Foxo1+,Igh-Jtm1Cgn/Ightm4Cgn,Tg(Cr2-cre)3Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptentm1Ppp/Ptentm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0011139 increased lung endothelial cell proliferation "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0011147 increased mesenchymal cell proliferation involved in lung development "increase in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

 MP:0011237 decreased blood oxygen capacity "a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood" [ISBN:0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Hoxb7-cre)5526Cmb/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0011336 abnormal kidney pelvis urothelium morphology "any structural anomaly of the epithelial lining of the luminal space of the kidney pelvis" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0011403 pyelonephritis "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Vhltm1Jae/Vhltm1Jae,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011766 abnormal urinary bladder mucosa morphology "any structural anomaly of the mucous membrane lining the urinary bladder" [MGI:anna]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0011789 increased urethra carcinoma incidence "greater than the expected number of malignant neoplasms arising from the epithelial lining of the urethra in a given population in a given time period" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0011874 enlarged urinary bladder "increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [MGI:Colin_McKerlie]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Stk11tm1Keis/Stk11tm1Keis,Tg(Cyp1a1-cre/ERT)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0012043 increased myoepithelioma incidence "greater than the expected occurrence of a benign tumor of myoepithelial cells, occurring in a specific population in a given time period" [ISBN:0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Trp53tm1Brn/Trp53tm1Brn,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0012065 increased astrocyte number "increase in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm1Mmt/Ctnnb1+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Trp53tm2Tyj/Trp53+,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Otx2tm1Sia/Otx2tm4Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ptentm1Mak/Pten+
Genetic Background: B6.129P2-Ptentm1Mak

Allelic Composition: Grb2tm1Paw/Grb2+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ptentm1.2Mwst/Pten+
Genetic Background: Not Specified

Allelic Composition: Ptentm1.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm2.1Gle/Pten+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

Allelic Composition: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+,Ptentm1.1Hwu/Pten+
Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Inpp5dtm1Rav/Inpp5dtm1Rav,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Ube2otm1.1(KOMP)Mbp/Ube2otm1.1(KOMP)Mbp,Ptentm1Ppp/Ptentm1Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6N * FVB/N

 MP:0012433 decreased ovarian tumor incidence "less than the expected number of neoplams in the ovary occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0012459 increased dentate gyrus size "greater size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0012550 respiratory acidosis "acidosis caused by retention of and increased blood carbon dioxide concentration, often caused by decreased ventilation (hypoventilation); results in decreased blood pH unless kidneys compensate by retaining bicarbonate" [ISBN:0-683-40008-8]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0012570 increased mammary gland tumor incidence in breeding females "greater than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0012674 tomacula "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: B6N.129-Cnptm1(cre)Kan Ptentm1Hwu

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
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Allelic Composition: Pik3catm1.1Waph/Pik3ca+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Apctm1Tno/Apctm1Tno,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0013218 abnormal substantia nigra pars reticulata morphology "any structural anomaly of the anterior (ventral) part of grey matter of the substantia nigra which contains smaller and loosely packed cells than the pars compacta, only some of which contain a small amount of pigment; the cells of pars reticulata bear a strong structural and functional resemblance to the inner segment of the globus pallidus; many cells in this region use GABA as a neurotransmitter" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013221 pancreatic acinar-to-ductal metaplasia "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0013399 endometrium fibrosis "invasion of fibrous connective tissue into the endometrium, often resulting from inflammation or injury" [MGI:Anna]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0013693 abnormal hemopoiesis "any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

 MP:0014038 increased hepatocyte number "greater than normal number of parenchymal liver cells" [MGI:monikat]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0014045 Mallory bodies "stereotypical manifestations of hepatocyte injury that present as cytoplasmic inclusion bodies consisting of intermediate filament components (e.g., modified cytokeratins, chaperones and protein degradation machinery)" [PMID:17531973, PMID:7927209]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0014049 increased T cell acute lymphoblastic leukemia incidence "an aggressive (fast-growing) type of leukemia (blood cancer) in which too many T-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood" [NCIT:C3183]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu

 MP:0014081 branched small intestinal villi "atypical formation of branched tree-like structures in the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; branching may occur in association with increased or ectopic epithelial proliferation" [MGI:Anna, PMID:16679353]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J * SJL

 MP:0020410 increased liposarcoma incidence "greater than the expected number of malignant tumors derived from primitive or embryonal lipoblastic cells; these may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid, round-celled, or pleomorphic" [MESH:D008080, PMID:27573812]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021326 Q62158 / Trim27 / Zinc finger protein RFP / P14373* / tripartite motif containing 27*  / complex / reaction
 ENSMUSG00000019779 Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000048960 Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*  / complex / reaction
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / reaction
 ENSMUSG00000024811 Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*  / reaction
 ENSMUSG00000031529 Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*  / reaction
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / reaction
 ENSMUSG00000056900 Usp13 / Q5BKP2 / ubiquitin specific peptidase 13 (isopeptidase T-3) / Q92995* / ubiquitin specific peptidase 13*  / reaction
 ENSMUSG00000041161 Otud3 / B1AZ99 / OTU domain-containing protein 3 / Q5T2D3* / OTU deubiquitinase 3*  / reaction
 ENSMUSG00000022710 Usp7 / ubiquitin specific peptidase 7 / Q93009*  / reaction
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / reaction






 

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