ENSMUSG00000019779


Mus musculus

Features
Gene ID: ENSMUSG00000019779
  
Biological name :Frk
  
Synonyms : Frk / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / Q922K9
  
Possible biological names infered from orthology : fyn related Src family tyrosine kinase / P42685
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 34483399
Gene end: 34611278
  
Corresponding Affymetrix probe sets: 10362499 (MoGene1.0st)   1421362_a_at (Mouse Genome 430 2.0 Array)   1426569_a_at (Mouse Genome 430 2.0 Array)   1426570_a_at (Mouse Genome 430 2.0 Array)   1436413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019913
Ensembl peptide - ENSMUSP00000130289
NCBI entrez gene - 14302     See in Manteia.
MGI - MGI:103265
RefSeq - XM_006512536
RefSeq - NM_001159544
RefSeq - NM_001358769
RefSeq - NM_010237
RefSeq - XM_006512534
RefSeq - XM_006512535
RefSeq Peptide - NP_001153016
RefSeq Peptide - NP_001345698
RefSeq Peptide - NP_034367
swissprot - Q922K9
Ensembl - ENSMUSG00000019779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frkENSDARG00000027807Danio rerio
 FRKENSGALG00000014979Gallus gallus
 FRKENSG00000111816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984348
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887447
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764647
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222847
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445346
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040946
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328346
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493246
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875140
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757940


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035805  Tyrosine-protein kinase Frk, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / complex / reaction






 

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