ENSG00000111816


Homo sapiens

Features
Gene ID: ENSG00000111816
  
Biological name :FRK
  
Synonyms : FRK / fyn related Src family tyrosine kinase / P42685
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q22.1
Gene start: 115931149
Gene end: 116060758
  
Corresponding Affymetrix probe sets: 207178_s_at (Human Genome U133 Plus 2.0 Array)   235924_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476145
NCBI entrez gene - 2444     See in Manteia.
OMIM - 606573
RefSeq - XM_017010645
RefSeq - NM_002031
RefSeq - XM_011535655
RefSeq - XM_011535656
RefSeq - XM_005266880
RefSeq - XM_005266881
RefSeq - XM_005266882
RefSeq - XM_011535653
RefSeq - XM_011535654
RefSeq Peptide - NP_002022
swissprot - P42685
Ensembl - ENSG00000111816
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frkENSDARG00000027807Danio rerio
 FRKENSGALG00000014979Gallus gallus
 FrkENSMUSG00000019779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093849
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081049
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610548
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712248
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133648
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408747
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286646
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657346
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550840
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035805  Tyrosine-protein kinase Frk, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity EXP
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction / complex






 

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