ENSG00000101336


Homo sapiens

Features
Gene ID: ENSG00000101336
  
Biological name :HCK
  
Synonyms : HCK / HCK proto-oncogene, Src family tyrosine kinase / P08631
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.21
Gene start: 32052188
Gene end: 32101856
  
Corresponding Affymetrix probe sets: 208018_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000491964
Ensembl peptide - ENSP00000262651
Ensembl peptide - ENSP00000365012
Ensembl peptide - ENSP00000365022
Ensembl peptide - ENSP00000420457
Ensembl peptide - ENSP00000444986
Ensembl peptide - ENSP00000486627
Ensembl peptide - ENSP00000427757
Ensembl peptide - ENSP00000429848
Ensembl peptide - ENSP00000441169
NCBI entrez gene - 3055     See in Manteia.
OMIM - 142370
RefSeq - NM_001172129
RefSeq - NM_001172131
RefSeq - NM_001172132
RefSeq - NM_001172133
RefSeq - NM_002110
RefSeq - NM_001172130
RefSeq Peptide - NP_001165600
RefSeq Peptide - NP_001165602
RefSeq Peptide - NP_001165603
RefSeq Peptide - NP_001165604
RefSeq Peptide - NP_002101
RefSeq Peptide - NP_001165601
swissprot - P08631
swissprot - F6SF04
swissprot - H0Y3C5
swissprot - H7BXG4
swissprot - H7C5P9
swissprot - J3KPD6
Ensembl - ENSG00000101336
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hckENSDARG00000058647Danio rerio
 HCKENSGALG00000006522Gallus gallus
 HckENSMUSG00000003283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408768
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286663
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657361
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610560
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081058
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712255
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093855
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181646
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550836
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035851  Tyrosine-protein kinase HCK, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002522 leukocyte migration involved in immune response TAS
 biological_processGO:0002758 innate immune response-activating signal transduction TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043299 leukocyte degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045728 respiratory burst after phagocytosis TAS
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0050727 regulation of inflammatory response TAS
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0071801 regulation of podosome assembly IDA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005925 focal adhesion IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IMP
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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