ENSG00000125508


Homo sapiens

Features
Gene ID: ENSG00000125508
  
Biological name :SRMS
  
Synonyms : Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / SRMS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.33
Gene start: 63540810
Gene end: 63547504
  
Corresponding Affymetrix probe sets: 234514_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000217188
NCBI entrez gene - 6725     See in Manteia.
OMIM - 617797
RefSeq - NM_080823
RefSeq Peptide - NP_543013
swissprot - Q9H3Y6
Ensembl - ENSG00000125508
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SRMSENSDARG00000077783Danio rerio
 SRMSENSGALG00000005852Gallus gallus
 SrmsENSMUSG00000027579Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121342
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181641
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657341
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093841
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286641
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712240
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081040
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610539
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133639
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0009968 negative regulation of signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity EXP
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PTK6 Down-Regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction






 

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