ENSMUSG00000027579


Mus musculus

Features
Gene ID: ENSMUSG00000027579
  
Biological name :Srms
  
Synonyms : src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Srms
  
Possible biological names infered from orthology : Q9H3Y6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181205562
Gene end: 181213185
  
Corresponding Affymetrix probe sets: 10490621 (MoGene1.0st)   1449287_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016498
NCBI entrez gene - 20811     See in Manteia.
MGI - MGI:101865
RefSeq - NM_011481
RefSeq - XM_017316827
RefSeq Peptide - NP_035611
swissprot - Q0VBH4
Ensembl - ENSMUSG00000027579
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SRMSENSDARG00000077783Danio rerio
 SRMSENSGALG00000005852Gallus gallus
 SRMSENSG00000125508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875141
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764640
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977940
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984339
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445339
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887439
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328338
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040938
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493237
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PTK6 Down-Regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkrftm1.1Hjh/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction






 

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