ENSMUSG00000042228


Mus musculus

Features
Gene ID: ENSMUSG00000042228
  
Biological name :Lyn
  
Synonyms : Lyn / LYN proto-oncogene, Src family tyrosine kinase / P25911
  
Possible biological names infered from orthology : P07948
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 3678115
Gene end: 3813122
  
Corresponding Affymetrix probe sets: 10503098 (MoGene1.0st)   1425598_a_at (Mouse Genome 430 2.0 Array)   1451318_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038838
Ensembl peptide - ENSMUSP00000100075
NCBI entrez gene - 17096     See in Manteia.
MGI - MGI:96892
RefSeq - XM_011249939
RefSeq - NM_001111096
RefSeq - NM_010747
RefSeq Peptide - NP_034877
RefSeq Peptide - NP_001104566
swissprot - P25911
swissprot - Q3TCS3
swissprot - Q3U6Q5
Ensembl - ENSMUSG00000042228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lynENSDARG00000067916Danio rerio
 LYNENSGALG00000042321Gallus gallus
 LYNENSG00000254087Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328370
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040963
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445361
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984356
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493256
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887456
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764654
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977947
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757936
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035748  Tyrosine-protein kinase Lyn, SH3 domain
 IPR035852  Tyrosine-protein kinase Lyn, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0001817 regulation of cytokine production IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IMP
 biological_processGO:0002513 tolerance induction to self antigen IMP
 biological_processGO:0002553 histamine secretion by mast cell IEA
 biological_processGO:0002576 platelet degranulation IMP
 biological_processGO:0002762 negative regulation of myeloid leukocyte differentiation IMP
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway IMP
 biological_processGO:0002774 Fc receptor mediated inhibitory signaling pathway IMP
 biological_processGO:0002902 regulation of B cell apoptotic process IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0006991 response to sterol depletion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033003 regulation of mast cell activation IMP
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin ISO
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway IMP
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0042541 hemoglobin biosynthetic process TAS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043304 regulation of mast cell degranulation IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050707 regulation of cytokine secretion IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0050855 regulation of B cell receptor signaling pathway IMP
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IGI
 biological_processGO:0051272 positive regulation of cellular component movement ISO
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IGI
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:0070304 positive regulation of stress-activated protein kinase signaling cascade ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070447 positive regulation of oligodendrocyte progenitor proliferation IEA
 biological_processGO:0070667 negative regulation of mast cell proliferation IMP
 biological_processGO:0070668 positive regulation of mast cell proliferation ISO
 biological_processGO:0071300 cellular response to retinoic acid ISO
 biological_processGO:0090025 regulation of monocyte chemotaxis ISO
 biological_processGO:0090330 regulation of platelet aggregation IMP
 biological_processGO:0097028 dendritic cell differentiation IMP
 biological_processGO:1902532 negative regulation of intracellular signal transduction IMP
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0034666 integrin alpha2-beta1 complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005128 erythropoietin receptor binding TAS
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0043208 glycosphingolipid binding IEA
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046875 ephrin receptor binding ISO
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0140031 phosphorylation-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Mhi/Lyntm1Mhi
Genetic Background: involves: 129S1/Sv

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: LynM1Btlr/LynM1Btlr
Genetic Background: C57BL/6J-LynM1Btlr

Allelic Composition: LynM1Btlr/Lyn+
Genetic Background: C57BL/6J-LynM1Btlr

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr1tm1Wfv/Ddr1tm1Wfv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cd36tm1Frm/Cd36tm1Frm
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Tyrp1b-3Btlr/Tyrp1b-3Btlr
Genetic Background: C57BL/6J-Tyrp1b-3Btlr

Allelic Composition: LynM3Btlr/Lyn+
Genetic Background: C57BL/6J-LynM3Btlr

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap2m2Btlr/Tap2m2Btlr
Genetic Background: C57BL/6J-Tap2m2Btlr

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tap2m2Btlr/Tap2m2Btlr
Genetic Background: C57BL/6J-Tap2m2Btlr

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev,Lyntm1Sor/Lyntm1Sor
Genetic Background: B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd36tm1Frm/Cd36tm1Frm
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002360 abnormal spleen B cell corona morphology "anomalous structure of the area of the splenic white pulp dominated by B lymphocyte follicles " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd36tm1Frm/Cd36tm1Frm
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ightm1Mnz/Ightm1Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ightm2Mnz/Ightm2Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev,Lyntm1Sor/Lyntm1Sor
Genetic Background: B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: Lyntm1Ard/Lyntm1Ard,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lynmld4/Lynmld4,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.129S1-Mpltm1Wsa

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

 MP:0004944 abnormal B cell negative selection "any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Mhi/Lyntm1Mhi
Genetic Background: involves: 129S1/Sv

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: LynM3Btlr/LynM3Btlr
Genetic Background: C57BL/6J-LynM3Btlr

Allelic Composition: LynM3Btlr/Lyn+
Genetic Background: C57BL/6J-LynM3Btlr

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il5ratm1Ktk/Il5ratm1Ktk,Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Blktm1Tara/Blktm1Tara,Fyntm1Sor/Fyntm1Sor,Lyntm1Ard/Lyntm1Ard
Genetic Background: either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lynm1Apb/Lynm1Apb
Genetic Background: C57BL/6JAnu-Lynm1Apb

Allelic Composition: LynM1Btlr/LynM1Btlr
Genetic Background: C57BL/6J-LynM1Btlr

Allelic Composition: LynM1Btlr/Lyn+
Genetic Background: C57BL/6J-LynM1Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrp1b-3Btlr/Tyrp1b-3Btlr
Genetic Background: C57BL/6J-Tyrp1b-3Btlr

Allelic Composition: LynM3Btlr/Lyn+
Genetic Background: C57BL/6J-LynM3Btlr

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Ightm1Mnz/Ightm1Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ightm2Mnz/Ightm2Mnz,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: LynM3Btlr/LynM3Btlr
Genetic Background: C57BL/6J-LynM3Btlr

Allelic Composition: LynM3Btlr/Lyn+
Genetic Background: C57BL/6J-LynM3Btlr

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: LynM3Btlr/LynM3Btlr
Genetic Background: C57BL/6J-LynM3Btlr

Allelic Composition: LynM3Btlr/Lyn+
Genetic Background: C57BL/6J-LynM3Btlr

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Ptpn6me-v/Ptpn6+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd22tm1Eac/Cd22+,Lyntm1Ard/Lyn+,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0008202 absent B-1 B cells "absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blktm1Tara/Blktm1Tara,Fyntm1Sor/Fyntm1Sor,Lyntm1Ard/Lyntm1Ard
Genetic Background: either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cd19tm1Tft/Cd19tm1Tft,Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lynm2Anu/Lynm2Anu
Genetic Background: C57B/6JAnu-Lynm2Anu/AnuApb

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lynm2Anu/Lynm2Anu
Genetic Background: C57B/6JAnu-Lynm2Anu/AnuApb

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blktm1Tara/Blktm1Tara,Fyntm1Sor/Fyntm1Sor,Lyntm1Ard/Lyntm1Ard
Genetic Background: either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lyntm1Ard/Lyntm1Ard,Tg(IghelMD4)4Ccg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blktm1Tara/Blktm1Tara,Fyntm1Sor/Fyntm1Sor,Lyntm1Ard/Lyntm1Ard
Genetic Background: either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Tya/Lyntm1Tya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010215 abnormal circulating complement protein level "deviation from the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: KitW-sh/KitW-sh,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 101 * 129P2/OlaHsd * C3H/HeH

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Igh-7tm1Led/Igh-7tm1Led,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0011512 mesangial cell interposition "spreading of mesangial cells into the contiguous space between the adjacent glomerular endothelial cells and the glomerular basement membrane (GBM)" [MGI:anna]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Lynweeb/Lynweeb
Genetic Background: C57BL/6-Lynweeb

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Tap2m2Btlr/Tap2m2Btlr
Genetic Background: C57BL/6J-Tap2m2Btlr

Allelic Composition: LynM2Btlr/Lyn+
Genetic Background: C57BL/6J-LynM2Btlr

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Lynmld4/Lynmld4
Genetic Background: involves: C57BL/6

Allelic Composition: Lyntm1Ard/Lyntm1Ard
Genetic Background: B6.129P2-Lyntm1Ard

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000026259 Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex
 ENSMUSG00000024680 Ms4a2 / P20490 / membrane-spanning 4-domains, subfamily A, member 2 / Q01362* / membrane spanning 4-domains A2*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000003379 Cd79a / P11911 / B-cell antigen receptor complex-associated protein alpha chain / P11912* / CD79a molecule*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000040592 Cd79b / P15530 / B-cell antigen receptor complex-associated protein beta chain / P40259* / CD79b molecule*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000058715 Fcer1g / P20491 / High affinity immunoglobulin epsilon receptor subunit gamma / P30273* / Fc fragment of IgE receptor Ig*  / complex / reaction
 ENSMUSG00000005339 Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*  / complex / reaction
 ENSMUSG00000026778 Prkcq / Q02111 / protein kinase C, theta / Q04759*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / reaction / complex
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000078810 Gp6 / P0C191 / Platelet glycoprotein VI / Q9HCN6* / glycoprotein VI platelet*  / reaction / complex






 

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