ENSGALG00000042321


Gallus gallus

Features
Gene ID: ENSGALG00000042321
  
Biological name :LYN
  
Synonyms : LYN / LYN proto-oncogene, Src family tyrosine kinase
  
Possible biological names infered from orthology : P07948 / P25911
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 111489591
Gene end: 111536777
  
Corresponding Affymetrix probe sets: Gga.5758.1.S1_s_at (Chicken Array)   Gga.9541.1.A1_at (Chicken Array)   Gga.9541.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047115
NCBI entrez gene - 421127     See in Manteia.
RefSeq - XM_015282670
RefSeq - NM_001006390
RefSeq - XM_015282668
RefSeq - XM_015282669
RefSeq - XM_015282664
RefSeq - XM_015282665
RefSeq - XM_015282666
RefSeq - XM_015282667
RefSeq Peptide - NP_001006390
swissprot - Q5ZMB9
Ensembl - ENSGALG00000042321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lynENSDARG00000067916Danio rerio
 LYNENSG00000254087Homo sapiens
 LynENSMUSG00000042228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCK / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSGALG0000000652269
LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSGALG0000000046665
BLK / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSGALG0000001666162
YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*ENSGALG0000001486061
FGR / Q02977 / Proto-oncogene tyrosine-protein kinase Yrk ENSGALG0000003219959
FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*ENSGALG0000001502257
SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*ENSGALG0000000385557
FRK / fyn related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSGALG0000001497949
SRMS / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSGALG0000000585237


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:0002513 tolerance induction to self antigen IEA
 biological_processGO:0002576 platelet degranulation IEA
 biological_processGO:0002762 negative regulation of myeloid leukocyte differentiation IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway IEA
 biological_processGO:0002774 Fc receptor mediated inhibitory signaling pathway IEA
 biological_processGO:0002902 regulation of B cell apoptotic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0033003 regulation of mast cell activation IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043304 regulation of mast cell degranulation IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045646 regulation of erythrocyte differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0050855 regulation of B cell receptor signaling pathway IEA
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0051272 positive regulation of cellular component movement IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0070304 positive regulation of stress-activated protein kinase signaling cascade IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070667 negative regulation of mast cell proliferation IEA
 biological_processGO:0070668 positive regulation of mast cell proliferation IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0090025 regulation of monocyte chemotaxis IEA
 biological_processGO:0090330 regulation of platelet aggregation IEA
 biological_processGO:0097028 dendritic cell differentiation IEA
 biological_processGO:1902532 negative regulation of intracellular signal transduction IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0140031 phosphorylation-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
Fc epsilon receptor (FCERI) signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CD209 (DC-SIGN) signaling
Regulation of signaling by CBL
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / complex
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / reaction / complex
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex
 ENSGALG00000036327 NGEF / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / complex
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction / complex
 ENSGALG00000014855 GHR / growth hormone receptor precursor / P16882* / P10912* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr