ENSGALG00000015842


Gallus gallus

Features
Gene ID: ENSGALG00000015842
  
Biological name :TIAM1
  
Synonyms : T cell lymphoma invasion and metastasis 1 / TIAM1
  
Possible biological names infered from orthology : Q13009
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 104463378
Gene end: 104576084
  
Corresponding Affymetrix probe sets: Gga.12179.1.S1_at (Chicken Array)   Gga.12354.1.S1_at (Chicken Array)   Gga.12783.1.S1_s_at (Chicken Array)   Gga.8905.1.S1_at (Chicken Array)   GgaAffx.21083.1.S1_s_at (Chicken Array)   GgaAffx.24784.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025495
Ensembl peptide - ENSGALP00000046099
NCBI entrez gene - 418491     See in Manteia.
RefSeq - XM_416699
RefSeq - XM_015299682
RefSeq - XM_015299699
RefSeq - XM_004938381
RefSeq - XM_004938382
RefSeq - XM_015299657
RefSeq - XM_015299661
RefSeq - XM_015299665
RefSeq - XM_015299674
swissprot - E1BS21
swissprot - A0A1D5P0C4
Ensembl - ENSGALG00000015842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam1aENSDARG00000078430Danio rerio
 tiam1bENSDARG00000025920Danio rerio
 TIAM1ENSG00000156299Homo sapiens
 Tiam1ENSMUSG00000002489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600539
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG000000046218
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG000000064398
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG000000021937
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG000000393277
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG000000076087
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG000000423547
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG000000026997
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG000000346746
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG000000310096
ENSGALG000000018943
ENSGALG000000362530


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily
 IPR033360  T-lymphoma invasion and metastasis-inducing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / complex / reaction
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / reaction / complex
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / reaction / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction / complex






 

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