ENSGALG00000003855


Gallus gallus

Features
Gene ID: ENSGALG00000003855
  
Biological name :SRC
  
Synonyms : P00523 / Proto-oncogene tyrosine-protein kinase Src / SRC
  
Possible biological names infered from orthology : Neuronal proto-onco tyrosine-protein kinase Src / P05480 / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 5211688
Gene end: 5229299
  
Corresponding Affymetrix probe sets: Gga.4959.1.S1_s_at (Chicken Array)   Gga.9449.1.S1_at (Chicken Array)   Gga.9450.1.S1_s_at (Chicken Array)   Gga.9451.1.S1_at (Chicken Array)   GgaAffx.21812.1.S1_s_at (Chicken Array)   GgaAffx.26027.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006117
Ensembl peptide - ENSGALP00000063464
Ensembl peptide - ENSGALP00000061307
Ensembl peptide - ENSGALP00000060802
Ensembl peptide - ENSGALP00000049896
NCBI entrez gene - 396442     See in Manteia.
RefSeq - XM_015296345
RefSeq - XM_015296348
RefSeq - XM_015296347
RefSeq - XM_015296346
RefSeq - NM_205457
RefSeq Peptide - NP_990788
swissprot - P00523
swissprot - A0A1L1RR80
swissprot - A0A1D5PAX9
swissprot - A0A1I7Q3Z0
swissprot - A0A1L1RPS8
Ensembl - ENSGALG00000003855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srcENSDARG00000008107Danio rerio
 SRCENSG00000197122Homo sapiens
 SrcENSMUSG00000027646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*ENSGALG0000001486072
FGR / Q02977 / Proto-oncogene tyrosine-protein kinase Yrk ENSGALG0000003219966
FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*ENSGALG0000001502266
HCK / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSGALG0000000652253
LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSGALG0000000046652
LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*ENSGALG0000004232150
BLK / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSGALG0000001666150
FRK / fyn related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSGALG0000001497944
SRMS / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSGALG0000000585235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IBA
 biological_processGO:0036035 osteoclast development IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045453 bone resorption IBA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0050847 progesterone receptor signaling pathway IBA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0071801 regulation of podosome assembly IBA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IBA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0051427 hormone receptor binding IBA
 molecular_functionGO:0070851 growth factor receptor binding IBA
 molecular_functionGO:0071253 connexin binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
PIP3 activates AKT signaling
Spry regulation of FGF signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signaling by EGFR
GAB1 signalosome
Downstream signal transduction
c-src mediated regulation of Cx43 function and closure of gap junctions
FCGR activation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
Ephrin signaling
EPH-ephrin mediated repulsion of cells
ADP signalling through P2Y purinoceptor 1
DCC mediated attractive signaling
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
Thrombin signalling through proteinase activated receptors (PARs)
VEGFR2 mediated cell proliferation
RHO GTPases Activate Formins
MAP2K and MAPK activation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
MET activates PTK2 signaling
Receptor Mediated Mitophagy
Regulation of RUNX3 expression and activity
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / complex / reaction
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction / complex
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / reaction / complex
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000006462 PPP2CA / protein phosphatase 2 catalytic subunit alpha / P63330* / P67775* / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform *  / reaction
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / complex / reaction
 ENSGALG00000028187 E1BWM5 / FUNDC1 / FUN14 domain-containing protein 1 / Q8IVP5* / Q9DB70* / FUN14 domain containing 1*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / reaction / complex
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSGALG00000010273 P48463 / PPP2CB / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P62715* / P62714* / protein phosphatase 2 catalytic subunit beta* / Serine/threonine-protein pho...  / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / reaction
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000016564 PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex / reaction
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / reaction
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / reaction
 ENSGALG00000016906 SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*  / reaction
 ENSGALG00000042552 TJP1 / tight junction protein 1 / P39447* / Q07157*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / reaction / complex
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000016451 ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / reaction / complex
 ENSGALG00000027299 NTF3 / neurotrophin 3 / P20181* / P20783*  / reaction / complex
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / reaction
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction / complex
 ENSGALG00000036327 NGEF / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / complex
 ENSGALG00000023703 GIT1 / GIT ArfGAP 1 / Q68FF6* / Q9Y2X7* / ARF GTPase-activating protein GIT1 *  / reaction / complex
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / complex / reaction
 ENSGALG00000040241 NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*  / complex / reaction






 

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