ENSGALG00000000379


Gallus gallus

Features
Gene ID: ENSGALG00000000379
  
Biological name :ITGB3
  
Synonyms : ITGB3
  
Possible biological names infered from orthology : AC068234.1 / Integrin beta-3 / integrin subunit beta 3 / O54890 / P05106
  
Species: Gallus gallus
  
Chr. number: 27
Strand: 1
Band:
Gene start: 2474195
Gene end: 2491225
  
Corresponding Affymetrix probe sets: Gga.1039.1.S1_at (Chicken Array)   Gga.1039.2.S1_at (Chicken Array)   Gga.1039.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000518
NCBI entrez gene - 374209     See in Manteia.
RefSeq - NM_204315
RefSeq - XM_015299304
RefSeq Peptide - NP_989646
swissprot - Q92071
Ensembl - ENSGALG00000000379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb3aENSDARG00000056767Danio rerio
 itgb3bENSDARG00000045070Danio rerio
 AC068234.1ENSG00000259753Homo sapiens
 ITGB3ENSG00000259207Homo sapiens
 Itgb3ENSMUSG00000020689Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB5 / integrin beta-5 precursor / P18084* / integrin subunit beta 5*ENSGALG0000002976653
ITGB6 / integrin subunit beta 6 / P18564* / Q9Z0T9* / Integrin beta-6 *ENSGALG0000001114148
ITGB1 / integrin subunit beta 1 / P05556* / P09055* / Integrin beta-1 *ENSGALG0000000714544
ITGB2 / integrin beta-2 precursor / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *ENSGALG0000000751138
ITGB4 / integrin subunit beta 4 / A2A863* / P16144* / Integrin beta-4 *ENSGALG0000000238933
ITGB8 / integrin subunit beta 8 / P26012*ENSGALG0000001087532
ITGBL1 / integrin subunit beta like 1 / O95965* / Q8VDV0* / Integrin beta-like protein 1 *ENSGALG0000001686714


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR027068  Integrin beta-3 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0007044 cell-substrate junction assembly ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0030334 regulation of cell migration ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0061097 regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1903053 regulation of extracellular matrix organization IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0035866 alphav-beta3 integrin-PKCalpha complex IEA
 cellular_componentGO:0071133 alpha9-beta1 integrin-ADAM8 complex IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / reaction / complex
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000039990 TNC / tenascin C / P24821* / Q80YX1*  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000003283 COMP / cartilage oligomeric matrix protein / P49747* / Q9R0G6*  / complex / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction / complex
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000016564 PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*  / reaction / complex
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction






 

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