ENSGALG00000010290


Gallus gallus

Features
Gene ID: ENSGALG00000010290
  
Biological name :VEGFA
  
Synonyms : P67964 / Vascular endothelial growth factor A / VEGFA
  
Possible biological names infered from orthology : P15692 / Q00731
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 30739147
Gene end: 30759022
  
Corresponding Affymetrix probe sets: Gga.537.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053959
Ensembl peptide - ENSGALP00000016723
Ensembl peptide - ENSGALP00000050516
NCBI entrez gene - 395909     See in Manteia.
RefSeq - NM_001110355
RefSeq - NM_205042
RefSeq Peptide - NP_001103825
RefSeq Peptide - NP_990373
swissprot - A0A1D5PCM7
swissprot - Q540I2
swissprot - P67964
swissprot - F1NAQ1
Ensembl - ENSGALG00000010290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O73682ENSDARG00000103542Danio rerio
 vegfabENSDARG00000034700Danio rerio
 VEGFAENSG00000112715Homo sapiens
 VegfaENSMUSG00000023951Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PGF / placental growth factor / P49763* / P49764*ENSGALG0000002655731


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0001955 blood vessel maturation ISS
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031334 positive regulation of protein complex assembly ISS
 biological_processGO:0043117 positive regulation of vascular permeability ISS
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISS
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IBA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / reaction / complex
 ENSGALG00000001289 SHC2 / SHC adaptor protein 2 / P98077* / Q8BMC3* / SHC (Src homology 2 domain containing) transforming protein 2*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000016451 ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSGALG00000016564 PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*  / reaction / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction / complex
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / reaction / complex
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / reaction / complex
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / reaction
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex






 

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