ENSGALG00000008934


Gallus gallus

Features
Gene ID: ENSGALG00000008934
  
Biological name :PIK3CA
  
Synonyms : phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / PIK3CA
  
Possible biological names infered from orthology : P42336 / P42337 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 17595786
Gene end: 17618335
  
Corresponding Affymetrix probe sets: GgaAffx.5619.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014504
NCBI entrez gene - 424971     See in Manteia.
RefSeq - NM_001004410
RefSeq Peptide - NP_001004410
swissprot - O42391
Ensembl - ENSGALG00000008934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3caENSDARG00000075456Danio rerio
 P42336ENSG00000121879Homo sapiens
 P42337ENSMUSG00000027665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSGALG0000000550540
PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*ENSGALG0000000258339
PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma / P48736* / Q9JHG7* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform *ENSGALG0000000808130
PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSGALG0000000612126
PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSGALG0000003704324
PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747* / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 *ENSGALG0000001311723
PIK3C3 / phosphatidylinositol 3-kinase catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSGALG0000003577318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007163 establishment or maintenance of cell polarity IMP
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030031 cell projection assembly IMP
 biological_processGO:0030168 platelet activation IBA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0043457 regulation of cellular respiration IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044029 hypomethylation of CpG island IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0060326 cell chemotaxis IBA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0061642 chemoattraction of axon IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule IMP
 biological_processGO:0090527 actin filament reorganization IMP
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:0097485 neuron projection guidance IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 biological_processGO:2000653 regulation of genetic imprinting IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 cellular_componentGO:0005943 phosphatidylinositol 3-kinase complex, class IA IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032584 growth cone membrane IC
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IMP
 molecular_functionGO:1902379 chemoattractant activity involved in axon guidance IMP


Pathways (from Reactome)
Pathway description
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction / complex
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / complex / reaction
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex
 ENSGALG00000008669 CD28 / P31043 / T-cell-specific surface glycoprotein CD28 homolog / P31041* / P10747* / CD28 molecule* / T-cell-specific surface glycoprotein CD28 *  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000012456 RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSGALG00000013929 PDGFRA / platelet derived growth factor receptor alpha / P16234* / P26618* / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA.*  / reaction / complex
 ENSGALG00000026995 RHOG / ras homolog family member G / P84095* / P84096*  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / reaction / complex
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / reaction / complex
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000023781 TREM2 / triggering receptor expressed on myeloid cells 2 / Q99NH8* / Q9NZC2*  / reaction / complex
 ENSGALG00000030613 PDGFRB / platelet derived growth factor receptor beta / P09619* / platelet-derived growth factor receptor beta isoform 2 *  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / reaction / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / reaction / complex
 ENSGALG00000003642 PDGFA / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000012178 PDGFB / platelet derived growth factor subunit B / P01127* / platelet derived growth factor, B polypeptide*  / reaction / complex
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction / complex
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / complex / reaction
 ENSGALG00000015177 GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex
 ENSGALG00000010335 Q64143* / PIK3R3* / Q92569* / AL358075.4* / AL670603.1* / phosphoinositide-3-kinase regulatory subunit 3* / Phosphatidylinositol 3-kinase regulatory subunit gamma *  / complex
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / complex
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / reaction / complex
 ENSGALG00000011206 KITLG / Q09108 / Kit ligand Processed kit ligand / Kitl* / P20826* / P21583* / KIT ligand* / Kit ligand Soluble KIT ligand*  / reaction / complex
 ENSGALG00000015176 GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSGALG00000014362 CD86 / CD86 molecule / P42081* / P42082* / T-lymphocyte activation antigen CD86 *  / reaction / complex
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / complex
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / complex / reaction
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / reaction / complex
 ENSGALG00000031387 YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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