ENSGALG00000012456


Gallus gallus

Features
Gene ID: ENSGALG00000012456
  
Biological name :RAC2
  
Synonyms : RAC2 / Rac family small GTPase 2
  
Possible biological names infered from orthology : P15153 / Q05144 / Ras-related C3 botulinum toxin substrate 2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 51448385
Gene end: 51457486
  
Corresponding Affymetrix probe sets: Gga.6387.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037001
NCBI entrez gene - 418044     See in Manteia.
RefSeq - NM_001201452
RefSeq Peptide - NP_001188381
swissprot - Q5F337
Ensembl - ENSGALG00000012456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac2ENSDARG00000038010Danio rerio
 RAC2ENSG00000128340Homo sapiens
 Rac2ENSMUSG00000033220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*ENSGALG0000000713092
RAC3 / Rac family small GTPase 3 / P60763* / P60764* / RAS-related C3 botulinum substrate 3*ENSGALG0000004060689
RHOGLENSGALG0000000547570
CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *ENSGALG0000000479669
RHOG / ras homolog family member G / P84095* / P84096*ENSGALG0000002699569
RHOQ / rho-related GTP-binding protein RhoQ / P17081* / Q8R527* / ras homolog family member Q*ENSGALG0000001001061
RHOJ / rho-related GTP-binding protein RhoJ / Q9ER71* / Q9H4E5* / ras homolog family member J*ENSGALG0000001185559
RHOU* / Q7L0Q8* / Q9EQT3* / ras homolog family member U* / Rho-related GTP-binding protein RhoU *ENSGALG0000002573855
RHOV / ras homolog family member V / Q8VDU1* / Q96L33* / Rho-related GTP-binding protein RhoV *ENSGALG0000002804753
RHOBTB2 / Rho related BTB domain containing 2 / Q91V93* / Q9BYZ6* / Rho-related BTB domain-containing protein 2 *ENSGALG0000003402042
RHOBTB1 / Rho related BTB domain containing 1 / O94844* / Q9DAK3* / Rho-related BTB domain-containing protein 1 *ENSGALG0000000307342


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010810 regulation of cell-substrate adhesion IEA
 biological_processGO:0030031 cell projection assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0042129 regulation of T cell proliferation IEA
 biological_processGO:0043304 regulation of mast cell degranulation IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0060263 regulation of respiratory burst IEA
 biological_processGO:0060753 regulation of mast cell chemotaxis IEA
 biological_processGO:0071593 lymphocyte aggregation IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1902622 regulation of neutrophil migration IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
G alpha (12/13) signalling events
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004700 NCF2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / reaction / complex
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000016261 CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000029367 CYBA / cytochrome b-245 alpha chain / P13498* / Q61462* / Cytochrome b-245 light chain *  / reaction / complex






 

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