ENSGALG00000016261


Gallus gallus

Features
Gene ID: ENSGALG00000016261
  
Biological name :CYBB
  
Synonyms : CYBB / cytochrome b-245 beta chain
  
Possible biological names infered from orthology : Cytochrome b-245 heavy chain / P04839 / Q61093
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 113150989
Gene end: 113183645
  
Corresponding Affymetrix probe sets: GgaAffx.10393.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026172
Ensembl peptide - ENSGALP00000048231
Ensembl peptide - ENSGALP00000046007
Ensembl peptide - ENSGALP00000045823
NCBI entrez gene - 418581     See in Manteia.
RefSeq - NM_001100286
RefSeq - XM_015301814
RefSeq Peptide - NP_001093756
swissprot - A7E3K8
swissprot - A0A1D5NZK5
swissprot - A0A1D6UPU5
swissprot - A0A1D5P6A6
Ensembl - ENSGALG00000016261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cybbENSDARG00000056615Danio rerio
 CYBBENSG00000165168Homo sapiens
 CybbENSMUSG00000015340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOX3 / NADPH oxidase 3 / Q672J9* / Q9HBY0*ENSGALG0000001365956
NOX1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*ENSGALG0000000670754
NOX4 / NADPH oxidase 4 / Q9JHI8* / Q9NPH5*ENSGALG0000001723536
DUOX1* / DUOX2* / Q9NRD8* / Q9NRD9* / dual oxidase 1* / dual oxidase 2*ENSGALG0000004151029
NOX5 / NADPH oxidase 5 / Q96PH1*ENSGALG0000000806326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000012456 RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSGALG00000004700 NCF2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex
 ENSGALG00000017235 NOX4 / NADPH oxidase 4 / Q9JHI8* / Q9NPH5*  / complex
 ENSGALG00000029367 CYBA / cytochrome b-245 alpha chain / P13498* / Q61462* / Cytochrome b-245 light chain *  / complex






 

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