ENSDARG00000056615


Danio rerio

Features
Gene ID: ENSDARG00000056615
  
Biological name :cybb
  
Synonyms : cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease)
  
Possible biological names infered from orthology : cytochrome b-245 beta chain / Cytochrome b-245 heavy chain / P04839 / Q61093
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 29795155
Gene end: 29818866
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000073592
Ensembl peptide - ENSDARP00000143691
NCBI entrez gene - 393386     See in Manteia.
RefSeq - NM_200414
RefSeq Peptide - NP_956708
swissprot - F1QV52
swissprot - A0A286Y943
ZFIN ID - ZDB-GENE-040426-1380
Ensembl - ENSDARG00000056615
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYBBENSGALG00000016261Gallus gallus
 CYBBENSG00000165168Homo sapiens
 CybbENSMUSG00000015340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nox1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*ENSDARG0000008757460
duox / dual oxidase / DUOX1* / DUOX2* / Q9NRD9* / Q9NRD8* / dual oxidase 1* / dual oxidase 2*ENSDARG0000006263228
nox5 / NADPH oxidase, EF-hand calcium binding domain 5 / Q96PH1* / NADPH oxidase 5*ENSDARG0000007977328
NOX4 / NADPH oxidase 4 / Q9NPH5*ENSDARG0000011493715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism reactive oxygen species decreased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018283 cyba / cytochrome b-245, alpha polypeptide / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSDARG00000040812 ncf4 / neutrophil cytosolic factor 4 / P97369* / Q15080* / Neutrophil cytosol factor 4 *  / complex
 ENSDARG00000005821 ncf2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr