ENSDARG00000018283


Danio rerio

Features
Gene ID: ENSDARG00000018283
  
Biological name :cyba
  
Synonyms : cyba / cytochrome b-245, alpha polypeptide
  
Possible biological names infered from orthology : cytochrome b-245 alpha chain / Cytochrome b-245 light chain / P13498 / Q61462
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 31073265
Gene end: 31075619
  
Corresponding Affymetrix probe sets: Dr.17749.1.A1_at (Zebrafish Array)   Dr.17749.2.A1_a_at (Zebrafish Array)   NM_200579_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000014491
NCBI entrez gene - 393551     See in Manteia.
RefSeq - NM_200579
RefSeq Peptide - NP_956873
swissprot - Q6PH62
ZFIN ID - ZDB-GENE-040426-1526
Ensembl - ENSDARG00000018283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYBAENSGALG00000029367Gallus gallus
 CYBAENSG00000051523Homo sapiens
 CybaENSMUSG00000006519Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007732  Cytochrome b558 alpha-subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042554 superoxide anion generation IBA
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990266 neutrophil migration IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009141 macrophage macrophage response to wounding process quality , abnormal
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 ZFA:0009327 neutrophil neutrophil response to wounding process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000056374 noxo1b / NADPH oxidase organizer 1b / NOXO1* / Q8NFA2* / Q8VCM2* / NADPH oxidase organizer 1*  / complex
 ENSDARG00000087574 nox1 / NADPH oxidase 1 / Q8CIZ9* / Q9Y5S8*  / complex
 ENSDARG00000005821 ncf2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex
 ENSDARG00000040812 ncf4 / neutrophil cytosolic factor 4 / P97369* / Q15080* / Neutrophil cytosol factor 4 *  / complex
 ENSDARG00000056615 cybb / cytochrome b-245, beta polypeptide (chronic granulomatous disease) / Q61093* / P04839* / cytochrome b-245 beta chain* / Cytochrome b-245 heavy chain *  / complex
 ENSDARG00000038010 rac2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / reaction / complex






 

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