ENSGALG00000029367


Gallus gallus

Features
Gene ID: ENSGALG00000029367
  
Biological name :CYBA
  
Synonyms : CYBA / cytochrome b-245 alpha chain
  
Possible biological names infered from orthology : Cytochrome b-245 light chain / P13498 / Q61462
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 18663342
Gene end: 18665323
  
Corresponding Affymetrix probe sets: Gga.6153.1.S1_s_at (Chicken Array)   GgaAffx.12107.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050068
NCBI entrez gene - 100859840     See in Manteia.
RefSeq - XM_015292663
swissprot - Q5ZKT0
Ensembl - ENSGALG00000029367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cybaENSDARG00000018283Danio rerio
 CYBAENSG00000051523Homo sapiens
 CybaENSMUSG00000006519Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007732  Cytochrome b558 alpha-subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0017004 cytochrome complex assembly IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070257 positive regulation of mucus secretion IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:1900426 positive regulation of defense response to bacterium IEA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000016261 CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *  / complex
 ENSGALG00000004700 NCF2 / neutrophil cytosolic factor 2 / O70145* / P19878* / Neutrophil cytosol factor 2 *  / complex
 ENSGALG00000017235 NOX4 / NADPH oxidase 4 / Q9JHI8* / Q9NPH5*  / complex
 ENSGALG00000008952 NOXA1 / NADPH oxidase activator 1 / Q86UR1* / Q8CJ00*  / complex
 ENSGALG00000005572 NOXO1 / NADPH oxidase organizer 1 / Q8NFA2* / Q8VCM2*  / complex
 ENSGALG00000012456 RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction






 

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