ENSGALG00000004700


Gallus gallus

Features
Gene ID: ENSGALG00000004700
  
Biological name :NCF2
  
Synonyms : NCF2 / neutrophil cytosolic factor 2
  
Possible biological names infered from orthology : Neutrophil cytosol factor 2 / O70145 / P19878
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 7638601
Gene end: 7645618
  
Corresponding Affymetrix probe sets: Gga.17647.1.S1_at (Chicken Array)   Gga.17647.1.S1_s_at (Chicken Array)   GgaAffx.2916.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007475
NCBI entrez gene - 424445     See in Manteia.
RefSeq - XM_004943277
swissprot - F1NIH3
Ensembl - ENSGALG00000004700
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncf2ENSDARG00000005821Danio rerio
 NCF2ENSG00000116701Homo sapiens
 Ncf2ENSMUSG00000026480Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOXA1 / NADPH oxidase activator 1 / Q86UR1* / Q8CJ00*ENSGALG0000000895234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR001452  SH3 domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012456 RAC2 / Rac family small GTPase 2 / P15153* / Q05144* / Ras-related C3 botulinum toxin substrate 2 *  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000016261 CYBB / cytochrome b-245 beta chain / P04839* / Q61093* / Cytochrome b-245 heavy chain *  / complex
 ENSGALG00000029367 CYBA / cytochrome b-245 alpha chain / P13498* / Q61462* / Cytochrome b-245 light chain *  / complex






 

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