Manteia

ENSMUSG00000026480

Mus musculus

Features

Gene ID:	ENSMUSG00000026480

Biological name :	Ncf2

Synonyms :	Ncf2 / Neutrophil cytosol factor 2 / O70145

Possible biological names infered from orthology :	neutrophil cytosolic factor 2 / P19878

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	G3
Gene start:	152800194
Gene end:	152836991

Corresponding Affymetrix probe sets:	10350689 (MoGene1.0st) 10412123 (MoGene1.0st) 1448561_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000140404 Ensembl peptide - ENSMUSP00000027754 Ensembl peptide - ENSMUSP00000139774 NCBI entrez gene - 17970 See in Manteia. MGI - MGI:97284 RefSeq - NM_010877 RefSeq - XM_006529236 RefSeq Peptide - NP_035007 swissprot - A0A087WPH0 swissprot - O70145 Ensembl - ENSMUSG00000026480

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*	ENSMUSG00000036805	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000270	PB1 domain
IPR001440	Tetratricopeptide repeat 1
IPR001452	SH3 domain
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR013026	Tetratricopeptide repeat-containing domain
IPR019734	Tetratricopeptide repeat
IPR034885	Neutrophil cytosol factor 2, PB1 domain
IPR034889	Neutrophil cytosol factor 2
IPR035546	Neutrophil cytosol factor 2, SH3 domain 1
IPR036028	SH3-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006742	NADP catabolic process	ISO
biological_process	GO:0006801	superoxide metabolic process	ISO
biological_process	GO:0006909	phagocytosis	IEA
biological_process	GO:0042554	superoxide anion generation	IDA
biological_process	GO:0043085	positive regulation of catalytic activity	IEA
biological_process	GO:0045730	respiratory burst	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0001669	acrosomal vesicle	IDA
cellular_component	GO:0005730	nucleolus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0043020	NADPH oxidase complex	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008022	protein C-terminus binding	ISO
molecular_function	GO:0016175	superoxide-generating NADPH oxidase activity	ISO
molecular_function	GO:0016176	superoxide-generating NADPH oxidase activator activity	IEA
molecular_function	GO:0048365	Rac GTPase binding	IPI

Pathways (from Reactome)

Pathway description

ROS, RNS production in phagocytes

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000015950	Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*	/ complex
ENSMUSG00000015340	Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*	/ complex
ENSMUSG00000006519	Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*	/ complex
ENSMUSG00000033220	Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*	/ reaction / complex
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ reaction / complex
ENSMUSG00000023802	Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*	/ complex
ENSMUSG00000071715	Ncf4 / P97369 / Neutrophil cytosol factor 4 / Q15080* / neutrophil cytosolic factor 4*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr