ENSMUSG00000071715


Mus musculus

Features
Gene ID: ENSMUSG00000071715
  
Biological name :Ncf4
  
Synonyms : Ncf4 / Neutrophil cytosol factor 4 / P97369
  
Possible biological names infered from orthology : neutrophil cytosolic factor 4 / Q15080
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 78244801
Gene end: 78262580
  
Corresponding Affymetrix probe sets: 10425053 (MoGene1.0st)   1418465_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094084
Ensembl peptide - ENSMUSP00000121191
NCBI entrez gene - 17972     See in Manteia.
MGI - MGI:109186
RefSeq - XM_006520566
RefSeq - NM_008677
RefSeq - XM_006520564
RefSeq - XM_006520565
RefSeq Peptide - NP_032703
swissprot - A8XU21
swissprot - P97369
Ensembl - ENSMUSG00000071715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncf4ENSDARG00000040812Danio rerio
 NCF4ENSGALG00000038141Gallus gallus
 NCF4ENSG00000100365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000919  Neutrophil cytosol factor P40
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR034853  Neutrophil cytosol factor P40, PB1 domain
 IPR034912  Neutrophil cytosol factor 4, PX domain
 IPR035541  Neutrophil cytosol factor P40, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mir155tm1Rsky/Mir155tm1Rsky
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000015340 Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*  / complex
 ENSMUSG00000033220 Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*  / reaction / complex
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex






 

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