ENSMUSG00000001847


Mus musculus

Features
Gene ID: ENSMUSG00000001847
  
Biological name :Rac1
  
Synonyms : P63001 / Rac1 / RAS-related C3 botulinum substrate 1
  
Possible biological names infered from orthology : P63000 / Rac family small GTPase 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 143503634
Gene end: 143528036
  
Corresponding Affymetrix probe sets: 10535471 (MoGene1.0st)   1423734_at (Mouse Genome 430 2.0 Array)   1437674_at (Mouse Genome 430 2.0 Array)   1451086_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079380
Ensembl peptide - ENSMUSP00000098058
NCBI entrez gene - 19353     See in Manteia.
MGI - MGI:97845
RefSeq - XM_006504667
RefSeq - NM_001347530
RefSeq - NM_009007
RefSeq Peptide - NP_001334459
RefSeq Peptide - NP_033033
swissprot - P63001
swissprot - Q3TLP8
swissprot - K7Q7T7
Ensembl - ENSMUSG00000001847
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac1aENSDARG00000074849Danio rerio
 rac1bENSDARG00000087954Danio rerio
 rac1lENSDARG00000054649Danio rerio
 rac1lENSDARG00000096549Danio rerio
 si:ch211-1f22.1ENSDARG00000013203Danio rerio
 si:ch211-1f22.2ENSDARG00000096666Danio rerio
 RAC1ENSGALG00000007130Gallus gallus
 RAC1ENSG00000136238Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rac3 / P60764 / RAS-related C3 botulinum substrate 3 / P60763* / Rac family small GTPase 3*ENSMUSG0000001801284
Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*ENSMUSG0000003322083
Rhog / P84096 / ras homolog family member G / P84095*ENSMUSG0000007398265
Cdc42 / P60766 / Cell division control ENSMUSG0000000669964
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414358
Rhoj / Q9ER71 / ras homolog family member J / Q9H4E5*ENSMUSG0000004676854
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996053
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422648
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207540
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994440


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002093 auditory receptor cell morphogenesis IMP
 biological_processGO:0002551 mast cell chemotaxis IEA
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006972 hyperosmotic response IDA
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010591 regulation of lamellipodium assembly IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0014041 regulation of neuron maturation IGI
 biological_processGO:0016358 dendrite development IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021831 embryonic olfactory bulb interneuron precursor migration IMP
 biological_processGO:0021894 cerebral cortex GABAergic interneuron development IGI
 biological_processGO:0022604 regulation of cell morphogenesis IGI
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030041 actin filament polymerization IDA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0031529 ruffle organization IEA
 biological_processGO:0032707 negative regulation of interleukin-23 production IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IGI
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0043652 engulfment of apoptotic cell IDA
 biological_processGO:0045216 cell-cell junction organization IMP
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048532 anatomical structure arrangement IMP
 biological_processGO:0048812 neuron projection morphogenesis IGI
 biological_processGO:0048813 dendrite morphogenesis IGI
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051668 localization within membrane IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0051932 synaptic transmission, GABAergic IGI
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IGI
 biological_processGO:0060263 regulation of respiratory burst IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IGI
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0097178 ruffle assembly IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000242 pericentriolar material IDA
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0060091 kinocilium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0051022 Rho GDP-dissociation inhibitor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Signaling by SCF-KIT
NRAGE signals death through JNK
Rho GTPase cycle
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
PCP/CE pathway
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
Signal transduction by L1
VEGFR2 mediated vascular permeability
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate NADPH Oxidases
MAPK6/MAPK4 signaling
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
NTRK2 activates RAC1
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Frem1tm1Ksek/Frem1tm1Ksek
Genetic Background: involves: 129 * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sortm1(Dkk1)Flng,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rac1tm1Djk/Rac1tm1.1Djk,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0000557 absent hindlimb "missing the entire posterior extremities" [MGI:tc, J:54637]
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Allelic Composition: Gt(ROSA)26Sortm1(Dkk1)Flng/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

Allelic Composition: Rac1tm1Djk/Rac1tm1.1Djk,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0001213 abnormal skin cell number "greater than or fewer than the expected numbers of cells in the cutis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lyl1tm1Mago/Lyl1tm1Mago
Genetic Background: B6.129S7-Lyl1tm1Mago

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Frem1tm1Ksek/Frem1tm1Ksek
Genetic Background: involves: 129 * C57BL/6

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Achetm1.1Hssh/Achetm1.1Hssh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rac1tm1Brak/Rac1tm1Brak,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008222 decreased hippocampal commissure size "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: MmachcGt(AZ0348)Wtsi/MmachcGt(AZ0348)Wtsi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Emx1tm1(cre)Ito/Emx1+,Rac1tm1Atai/Rac1tm1Jms
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011190 thick embryonic epiblast "increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

Allelic Composition: Rac1tm2Tyb/Rac1tm2Tyb
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CD-1

Allelic Composition: Rac1tm2Tyb/Rac1tm2Tyb,Tg(Hhex-EGFP)#Rbe/0
Genetic Background: mixed

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA/J

Allelic Composition: Rac1tm2Tyb/Rac1tm2Tyb
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CD-1

 MP:0013377 abnormal sebocyte number "any deviation from the normal numbers of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [MGI:anna, PMID:19944183]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0020446 increased NAD(P)H oxidase activity "greater ability to catalyze the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide" [GO:0016174]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0030538 abnormal notochordal plate morphology "any structural anomaly of the dorsal part of the notochordal process when the ventral portion breaks down; it is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube; the folding off of the notochordal plate gives rise to the notochord" [UBERON:0006267]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000018293 Pfn1 / P62962 / profilin 1 / P07737*  / complex / reaction
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex
 ENSMUSG00000015340 Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / reaction
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / complex / reaction
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / complex / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / reaction / complex
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000049550 Clip1 / Q922J3 / CAP-Gly domain-containing linker protein 1 / P30622*  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000028068 Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000027805 Pfn2 / Q9JJV2 / Profilin-2 / P35080*  / reaction / complex
 ENSMUSG00000040940 Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*  / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / reaction
 ENSMUSG00000021676 Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*  / reaction / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction / complex
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / reaction
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000026425 Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...  / reaction / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex / reaction
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / reaction / complex
 ENSMUSG00000031257 Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*  / reaction / complex
 ENSMUSG00000074657 Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*  / complex / reaction
 ENSMUSG00000041498 Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / complex / reaction
 ENSMUSG00000038943 Prc1 / Q99K43 / protein regulator of cytokinesis 1 / O43663*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000024862 Klc2 / kinesin light chain 2 / Q9H0B6*  / complex / reaction
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000019320 Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / complex / reaction
 ENSMUSG00000023802 Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*  / reaction / complex
 ENSMUSG00000036805 Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*  / complex / reaction
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000050272 Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*  / complex / reaction
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex
 ENSMUSG00000071715 Ncf4 / P97369 / Neutrophil cytosol factor 4 / Q15080* / neutrophil cytosolic factor 4*  / complex / reaction
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / reaction
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr