ENSMUSG00000031257


Mus musculus

Features
Gene ID: ENSMUSG00000031257
  
Biological name :Nox1
  
Synonyms : NADPH oxidase 1 / Nox1 / Q8CIZ9
  
Possible biological names infered from orthology : Q9Y5S8
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 134086421
Gene end: 134221956
  
Corresponding Affymetrix probe sets: 10606640 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000123841
Ensembl peptide - ENSMUSP00000124355
Ensembl peptide - ENSMUSP00000124225
Ensembl peptide - ENSMUSP00000033610
Ensembl peptide - ENSMUSP00000108900
NCBI entrez gene - 237038     See in Manteia.
MGI - MGI:2450016
RefSeq - NM_172203
RefSeq - XM_006528515
RefSeq Peptide - NP_757340
swissprot - E0CYB0
swissprot - Q8CIZ9
swissprot - A0A0R4J1X7
Ensembl - ENSMUSG00000031257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nox1ENSDARG00000087574Danio rerio
 NOX1ENSGALG00000006707Gallus gallus
 NOX1ENSG00000007952Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*ENSMUSG0000001534056
Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*ENSMUSG0000002380252
Nox4 / Q9JHI8 / NADPH oxidase 4 / Q9NPH5*ENSMUSG0000003056237
Duox1 / dual oxidase 1 / Q9NRD9*ENSMUSG0000003326831
Duox2 / dual oxidase 2 / Q9NRD8*ENSMUSG0000006845228


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029650  NADPH oxidase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IMP
 biological_processGO:0006801 superoxide metabolic process ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process ISO
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045726 positive regulation of integrin biosynthetic process ISO
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0051454 intracellular pH elevation ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071455 cellular response to hyperoxia IMP
 biological_processGO:0072592 oxygen metabolic process IMP
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1990451 cellular stress response to acidic pH ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IMP
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043020 NADPH oxidase complex ISO
 cellular_componentGO:0071438 invadopodium membrane ISO
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0030171 voltage-gated proton channel activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding ISO


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

Allelic Composition: Nox1tm1.1Anrt/Nox1tm1.1Anrt,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wasltm2Sbs/Wasltm2Sbs,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
Show

Allelic Composition: Krt4Bcc1/Krt4+
Genetic Background: C3HeB/FeJ-Krt4Bcc1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000019320 Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*  / complex
 ENSMUSG00000036805 Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr