ENSG00000007952


Homo sapiens

Features
Gene ID: ENSG00000007952
  
Biological name :NOX1
  
Synonyms : NADPH oxidase 1 / NOX1 / Q9Y5S8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.1
Gene start: 100843324
Gene end: 100874345
  
Corresponding Affymetrix probe sets: 206418_at (Human Genome U133 Plus 2.0 Array)   207217_s_at (Human Genome U133 Plus 2.0 Array)   207380_x_at (Human Genome U133 Plus 2.0 Array)   210808_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000217885
Ensembl peptide - ENSP00000362055
Ensembl peptide - ENSP00000362057
Ensembl peptide - ENSP00000396992
Ensembl peptide - ENSP00000362051
NCBI entrez gene - 27035     See in Manteia.
OMIM - 300225
RefSeq - XM_017029407
RefSeq - NM_001271815
RefSeq - NM_007052
RefSeq - NM_013955
RefSeq Peptide - NP_039249
RefSeq Peptide - NP_001258744
RefSeq Peptide - NP_008983
swissprot - A6NGA6
swissprot - H0Y581
swissprot - Q5H9D4
swissprot - Q9Y5S8
Ensembl - ENSG00000007952
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nox1ENSDARG00000087574Danio rerio
 NOX1ENSGALG00000006707Gallus gallus
 Nox1ENSMUSG00000031257Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYBB / P04839 / cytochrome b-245 beta chainENSG0000016516859
NOX3 / Q9HBY0 / NADPH oxidase 3ENSG0000007477156
NOX4 / Q9NPH5 / NADPH oxidase 4ENSG0000008699137
NOX5 / Q96PH1 / NADPH oxidase 5ENSG0000025534630
DUOX1 / Q9NRD9 / dual oxidase 1ENSG0000013785730
DUOX2 / Q9NRD8 / dual oxidase 2ENSG0000014027929


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029650  NADPH oxidase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IEA
 biological_processGO:0006739 NADP metabolic process IC
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045726 positive regulation of integrin biosynthetic process IMP
 biological_processGO:0045730 respiratory burst TAS
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISS
 biological_processGO:0051454 intracellular pH elevation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0072592 oxygen metabolic process IEA
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1990451 cellular stress response to acidic pH IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043020 NADPH oxidase complex IDA
 cellular_componentGO:0071438 invadopodium membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IPI
 molecular_functionGO:0050661 NADP binding IC


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000188747 NOXA1 / Q86UR1 / NADPH oxidase activator 1  / complex
 ENSG00000196408 NOXO1 / Q8NFA2 / NADPH oxidase organizer 1  / complex
 ENSG00000051523 CYBA / P13498 / cytochrome b-245 alpha chain  / complex






 

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