ENSG00000137857


Homo sapiens

Features
Gene ID: ENSG00000137857
  
Biological name :DUOX1
  
Synonyms : dual oxidase 1 / DUOX1 / Q9NRD9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.1
Gene start: 45129933
Gene end: 45165576
  
Corresponding Affymetrix probe sets: 1565795_at (Human Genome U133 Plus 2.0 Array)   215800_at (Human Genome U133 Plus 2.0 Array)   219597_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373689
Ensembl peptide - ENSP00000454065
Ensembl peptide - ENSP00000454121
Ensembl peptide - ENSP00000317997
Ensembl peptide - ENSP00000452623
NCBI entrez gene - 53905     See in Manteia.
OMIM - 606758
RefSeq - XM_011521682
RefSeq - NM_017434
RefSeq - NM_175940
RefSeq - XM_011521681
RefSeq Peptide - NP_059130
RefSeq Peptide - NP_787954
swissprot - H0YNR5
swissprot - Q9NRD9
swissprot - H0YK19
Ensembl - ENSG00000137857
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 duoxENSDARG00000062632Danio rerio
 ENSGALG00000041510Gallus gallus
 Duox1ENSMUSG00000033268Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUOX2 / Q9NRD8 / dual oxidase 2ENSG0000014027978
NOX5 / Q96PH1 / NADPH oxidase 5ENSG0000025534614
CYBB / P04839 / cytochrome b-245 beta chainENSG0000016516811
NOX1 / Q9Y5S8 / NADPH oxidase 1ENSG0000000795211
NOX4 / Q9NPH5 / NADPH oxidase 4ENSG0000008699110
NOX3 / Q9HBY0 / NADPH oxidase 3ENSG0000007477110


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR010255  Haem peroxidase
 IPR011992  EF-hand domain pair
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018247  EF-Hand 1, calcium-binding site
 IPR019791  Haem peroxidase, animal type
 IPR029595  Dual oxidase 1/Duox
 IPR034821  Dual oxidase, peroxidase domain
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006590 thyroid hormone generation TAS
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0042335 cuticle development IMP
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0042554 superoxide anion generation NAS
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0050665 hydrogen peroxide biosynthetic process NAS
 biological_processGO:0051591 response to cAMP ISS
 biological_processGO:0055114 oxidation-reduction process TAS
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane NAS
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016174 NAD(P)H oxidase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050661 NADP binding NAS


Pathways (from Reactome)
Pathway description
Thyroxine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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