ENSG00000086991


Homo sapiens

Features
Gene ID: ENSG00000086991
  
Biological name :NOX4
  
Synonyms : NADPH oxidase 4 / NOX4 / Q9NPH5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.3
Gene start: 89324356
Gene end: 89498187
  
Corresponding Affymetrix probe sets: 219773_at (Human Genome U133 Plus 2.0 Array)   236843_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436093
Ensembl peptide - ENSP00000435474
Ensembl peptide - ENSP00000436716
Ensembl peptide - ENSP00000436970
Ensembl peptide - ENSP00000436892
Ensembl peptide - ENSP00000263317
Ensembl peptide - ENSP00000344747
Ensembl peptide - ENSP00000365146
Ensembl peptide - ENSP00000376961
Ensembl peptide - ENSP00000412446
Ensembl peptide - ENSP00000433797
Ensembl peptide - ENSP00000434924
Ensembl peptide - ENSP00000435039
NCBI entrez gene - 50507     See in Manteia.
OMIM - 605261
RefSeq - XM_017017845
RefSeq - NM_001291926
RefSeq - NM_001291927
RefSeq - NM_001291929
RefSeq - NM_001300995
RefSeq - NM_016931
RefSeq - XM_006718849
RefSeq - XM_011542857
RefSeq - XM_017017841
RefSeq - XM_017017842
RefSeq - XM_017017843
RefSeq - XM_017017844
RefSeq - NM_001143836
RefSeq - NM_001143837
RefSeq Peptide - NP_001137309
RefSeq Peptide - NP_001278858
RefSeq Peptide - NP_001287924
RefSeq Peptide - NP_058627
RefSeq Peptide - NP_001137308
RefSeq Peptide - NP_001278855
RefSeq Peptide - NP_001278856
swissprot - E9PPP2
swissprot - E9PI95
swissprot - E9PR43
swissprot - Q9NPH5
Ensembl - ENSG00000086991
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX4ENSDARG00000114937Danio rerio
 NOX4ENSGALG00000017235Gallus gallus
 Nox4ENSMUSG00000030562Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYBB / P04839 / cytochrome b-245 beta chainENSG0000016516838
NOX1 / Q9Y5S8 / NADPH oxidase 1ENSG0000000795236
NOX3 / Q9HBY0 / NADPH oxidase 3ENSG0000007477136
DUOX1 / Q9NRD9 / dual oxidase 1ENSG0000013785728
DUOX2 / Q9NRD8 / dual oxidase 2ENSG0000014027928
NOX5 / Q96PH1 / NADPH oxidase 5ENSG0000025534624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006801 superoxide metabolic process IDA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007569 cell aging ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0042554 superoxide anion generation ISS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0050667 homocysteine metabolic process IDA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016174 NAD(P)H oxidase activity TAS
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019826 oxygen sensor activity TAS
 molecular_functionGO:0020037 heme binding TAS
 molecular_functionGO:0050660 flavin adenine dinucleotide binding TAS
 molecular_functionGO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor IEA
 molecular_functionGO:0072341 modified amino acid binding IDA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000051523 CYBA / P13498 / cytochrome b-245 alpha chain  / complex
 ENSG00000165168 CYBB / P04839 / cytochrome b-245 beta chain  / complex






 

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