ENSG00000255346


Homo sapiens

Features
Gene ID: ENSG00000255346
  
Biological name :NOX5
  
Synonyms : NADPH oxidase 5 / NOX5 / Q96PH1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q23
Gene start: 68930525
Gene end: 69062743
  
Corresponding Affymetrix probe sets: 1553023_a_at (Human Genome U133 Plus 2.0 Array)   220641_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373518
Ensembl peptide - ENSP00000432440
Ensembl peptide - ENSP00000455703
Ensembl peptide - ENSP00000454143
Ensembl peptide - ENSP00000410887
Ensembl peptide - ENSP00000416828
NCBI entrez gene - 79400     See in Manteia.
OMIM - 606572
RefSeq - NM_001184779
RefSeq - NM_001184780
RefSeq - NM_024505
RefSeq Peptide - NP_078781
RefSeq Peptide - NP_001171708
RefSeq Peptide - NP_001171709
swissprot - Q96PH1
swissprot - A0A0B4J289
Ensembl - ENSG00000255346
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nox5ENSDARG00000079773Danio rerio
 NOX5ENSGALG00000008063Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUOX1 / Q9NRD9 / dual oxidase 1ENSG0000013785728
DUOX2 / Q9NRD8 / dual oxidase 2ENSG0000014027927
NOX1 / Q9Y5S8 / NADPH oxidase 1ENSG0000000795222
CYBB / P04839 / cytochrome b-245 beta chainENSG0000016516821
NOX3 / Q9HBY0 / NADPH oxidase 3ENSG0000007477121
NOX4 / Q9NPH5 / NADPH oxidase 4ENSG0000008699118


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029648  NADPH oxidase 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001935 endothelial cell proliferation IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0010155 regulation of proton transport NAS
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0043012 regulation of fusion of sperm to egg plasma membrane NAS
 biological_processGO:0050663 cytokine secretion NAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061640 cytoskeleton-dependent cytokinesis NAS
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0015252 proton channel activity IDA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding NAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding NAS
 molecular_functionGO:0050661 NADP binding NAS


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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