ENSG00000196408


Homo sapiens

Features
Gene ID: ENSG00000196408
  
Biological name :NOXO1
  
Synonyms : NADPH oxidase organizer 1 / NOXO1 / Q8NFA2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 1978917
Gene end: 1984192
  
Corresponding Affymetrix probe sets: 235329_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348435
Ensembl peptide - ENSP00000454644
Ensembl peptide - ENSP00000456800
Ensembl peptide - ENSP00000346195
Ensembl peptide - ENSP00000380450
NCBI entrez gene - 124056     See in Manteia.
OMIM - 611256
RefSeq - XM_017022928
RefSeq - NM_001267721
RefSeq - NM_144603
RefSeq - NM_172167
RefSeq - NM_172168
RefSeq - XM_005255099
RefSeq - XM_017022927
RefSeq Peptide - NP_751907
RefSeq Peptide - NP_751908
RefSeq Peptide - NP_001254650
RefSeq Peptide - NP_653204
swissprot - Q8NFA2
swissprot - H3BN18
Ensembl - ENSG00000196408
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noxo1aENSDARG00000041294Danio rerio
 noxo1bENSDARG00000056374Danio rerio
 NOXO1ENSGALG00000005572Gallus gallus
 Noxo1ENSMUSG00000019320Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCF1 / P14598 / neutrophil cytosolic factor 1ENSG0000015851723
Q5TCZ1 / SH3PXD2A / SH3 and PX domains 2AENSG0000010795722
A1X283 / SH3PXD2B / SH3 and PX domains 2BENSG0000017470519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR035758  NADPH oxidase organiser 1, second SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IBA
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process TAS
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0060263 regulation of respiratory burst TAS
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000007952 NOX1 / Q9Y5S8 / NADPH oxidase 1  / complex
 ENSG00000051523 CYBA / P13498 / cytochrome b-245 alpha chain  / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000188747 NOXA1 / Q86UR1 / NADPH oxidase activator 1  / complex






 

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