ENSMUSG00000019320


Mus musculus

Features
Gene ID: ENSMUSG00000019320
  
Biological name :Noxo1
  
Synonyms : NADPH oxidase organizer 1 / Noxo1 / Q8VCM2
  
Possible biological names infered from orthology : Q8NFA2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24696234
Gene end: 24700529
  
Corresponding Affymetrix probe sets: 10442565 (MoGene1.0st)   1425151_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019464
NCBI entrez gene - 71893     See in Manteia.
MGI - MGI:1919143
RefSeq - XM_017317652
RefSeq - NM_027988
RefSeq - XM_006524955
RefSeq - XM_011246629
RefSeq - XM_011246630
RefSeq - XM_006524949
RefSeq - XM_006524951
RefSeq Peptide - NP_082264
RefSeq Peptide - NP_001344765
swissprot - Q8VCM2
Ensembl - ENSMUSG00000019320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noxo1aENSDARG00000041294Danio rerio
 noxo1bENSDARG00000056374Danio rerio
 NOXO1ENSGALG00000005572Gallus gallus
 NOXO1ENSG00000196408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*ENSMUSG0000001595025
O89032 / Sh3pxd2a / SH3 and PX domain-containing protein 2A / Q5TCZ1* / SH3 and PX domains 2A*ENSMUSG0000005361724
A2AAY5 / Sh3pxd2b / SH3 and PX domain-containing protein 2B / A1X283* / SH3 and PX domains 2B*ENSMUSG0000004071121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR035758  NADPH oxidase organiser 1, second SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IDA
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0055114 oxidation-reduction process IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm1Sieg/Bdnftm1Sieg,Tg(Camk2a-cre)3Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000031257 Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*  / complex
 ENSMUSG00000036805 Noxa1 / Q8CJ00 / NADPH oxidase activator 1 / Q86UR1*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction






 

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