ENSMUSG00000036805


Mus musculus

Features
Gene ID: ENSMUSG00000036805
  
Biological name :Noxa1
  
Synonyms : NADPH oxidase activator 1 / Noxa1 / Q8CJ00
  
Possible biological names infered from orthology : Q86UR1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25085667
Gene end: 25095149
  
Corresponding Affymetrix probe sets: 10480585 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000037423
Ensembl peptide - ENSMUSP00000110014
NCBI entrez gene - 241275     See in Manteia.
MGI - MGI:2449980
RefSeq - NM_001163626
RefSeq - NM_172204
RefSeq Peptide - NP_001157098
RefSeq Peptide - NP_757341
swissprot - Q8CJ00
Ensembl - ENSMUSG00000036805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noxa1ENSDARG00000056047Danio rerio
 NOXA1ENSGALG00000008952Gallus gallus
 NOXA1ENSG00000188747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*ENSMUSG0000002648034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR001452  SH3 domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR034899  NADPH oxidase activator 1
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process ISO
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0060263 regulation of respiratory burst IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Noxa1tm1.2Brg/Noxa1tm1.2Brg
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex
 ENSMUSG00000023802 Nox3 / Q672J9 / NADPH oxidase 3 / Q9HBY0*  / complex
 ENSMUSG00000019320 Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*  / complex
 ENSMUSG00000031257 Nox1 / Q8CIZ9 / NADPH oxidase 1 / Q9Y5S8*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex






 

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